Blood serum phospholipid and red cell membrane spectra in patients with diabetes mellitus and antioxidant effects on these parameters

Abstract

Phospholipids are the main structural components of cell and subcellular membranes and determine the level of activity of membrane enzymes, tissue sensitivity to insulin. In the literature, the problem of phospholipid metabolism in diabetes mellitus (DM), including diabetic angiopathy, is not adequately addressed.

The aim of the study was to study the indicators of phospholipid metabolism in blood serum and erythrocyte membranes in patients with diabetes, as well as their dynamics under the influence of complex treatment with the inclusion of unitiol and tocopherol.

We examined 92 patients with type 1 diabetes (60 men and 32 women aged 17 to 45 years). The average severity of the disease was in 36 patients, the severe form of the disease was in 56. Diabetic angiopathies of various localization were noted in 63 patients. All patients upon admission to the hospital were in a state of decompensation of metabolic processes. The control group consisted of 24 healthy individuals of a similar age.