Androgen metabolism in male patients with type 1 diabetes mellitus
https://doi.org/10.14341/probl11578
Abstract
The purpose of this work was to study metabolism and peripheral blood content of the main adrenal and gonadal androgens (dehydroepiandrosterone (DHEA) and DHEA sulfate and testosterone, respectively) in men of different age treated by insulin. Thirty-five diabetics type I aged 15-52 years and 34 age-matched healthy controls were examined. The levels of DHEA and DHEA sulfate in the peripheral blood were decreased in the diabetics in comparison with healthy men, the differences being the most pronounced at the age of 15-45years. In parallel with this, hydrocortisone levels were increased in the patients. Opposite changes in the levels of adrenal androgens and hydrocortisone cause a drastic shift in these hormones balance in the patients with type I diabetes. The content of testosterone was normal (20.6 ± 1.2 nmol/liter) in 28 of 35patients during insulin therapy, while in 7 with higher glycaemia values the mean testosterone content was no higher than 6.3 + 1.1 nmol/liter. Presumably, the content of testosterone remains normal in diabetics during insulin therapy in the presence of adequate metabolic control, while the content of adrenal androgens decreases
About the Authors
N. P. GoncharovEndocrinology Research Centre, RAMS
Russian Federation
G. V. Katsiya
Endocrinology Research Centre, RAMS
Russian Federation
S. Yu. Kalinchenko
Endocrinology Research Centre, RAMS
Russian Federation
T. N. Todua
Endocrinology Research Centre, RAMS
Russian Federation
N. M. Malysheva
Endocrinology Research Centre, RAMS
Russian Federation
References
1. Adashi Е. Y., Fabrics С., Hsueh A. J. W. // Biol. Reprod. - 1982. - Vol. 26. - Р. 270-280.
2. Barrett-Connor Е., Khaw К. Т., Yen S. S. // New Engl. J. Med. - 1986. - Vol. 315. - P. 1519-1524.
3. Charreau E. H., Calvo J. C., Tesone M. et al. // J. Biol. Chem. - 1978. - Vol. 253. - P. 2504-2506.
4. Christensen L., Hagen C., Henrisken J. E., Haug E. // Dan. Med. Bull. - 1997. - Vol. 44, N 5. - P. 547-550.
5. Ebeling P., Stenman U. H., Seppala M., Koivisto V. A. // Clin. Endocrinol. - 1995. - Vol. 43, N 5. - P. 601-607.
6. Falkner B., Sherif K., Sumner A., Kushner H. // Metabolism. - Vol. 48, N 1. - P. 107-112.
7. Fushimi H., Horie H., Inouee T. et al. // Diabet. Res. Clin. Pract. - 1999. - Vol. 6. - P. 297-301.
8. Goncharov N. P., Kolesnikova G. S., Vorontsov В. I. et al. // Proceedings of the 5-th Symposium on the Analysis of Steroids. - Czombachey, 1993. - P. 407-426.
9. Lopez Blanco F., Fanjiul L. E, Ruiz de Galarreta С. M. // Endocrinology. - 1989. - Vol. 109. - P. 1248-1253.
10. Loviselli A., Pisanu P., Cossu E. // Minerva Endocrinol. - Vol. 19, N 3. - P. 113-119.
11. Morley J. E. // Diabet. Rev. - 1998. - Vol. 6, N I. - P. 6- 15.
12. Nestler J. E., Kahwash Z. // J. Clin. Invest. - 1984. - Vol. 94. - P. 1484-1489.
13. Nestler J. E., Barlascini С. O., Matt D. W. // J. Clin. Endocrinol. Metab. - 1989. - Vol. 68. - P. 1027-1032.
14. Nestler J. E., Usiskin K. S., Bartascini С. O. et al. // Ibid. - Vol. 69. - P 1040-1046.
15. Nestler J. E. // J. Basic Clin. Physiol. Pharmacol. - 1998. - Vol. 9, N 2-4. - P. 197-204.
16. Pasquali R., Casimirri F., De Lasio R. et al. // Clin. Endocrinol. - 1995. - Vol. 80. - P. 654-658.
17. Poretsky L. // Endocr. Rev. - 1991. - Vol. 12. - P. 3-12.
18. Sonka J., Vitokova M., Gregorova I. et al. // Endocrinologie. - Vol. 62. - P. 61-68.
19. Sufi S. B., Donaldson A., Jeffcoute S. L. // WHO. Matched Reagent Programme Method Manual. - 16-th Ed. - Lon don, 1992. - P. 16-84.
20. Walser M., Hill S. // Am. J. Kidney Dis. - 1997. - Vol. 29, N 4. - P. 503-513.
21. Yamatichi A., Takei 1., Kasuga A. et al. // Eur. J. Endocrinol. - 1966. - Vol. 135. - P. 101-104.
22. Zarady Z., Viktora J., Wolff F. V. // Metabolism. - 1966. - Vol. 15. - P. 257-261.
Review
For citations:
Goncharov N.P., Katsiya G.V., Kalinchenko S.Yu., Todua T.N., Malysheva N.M. Androgen metabolism in male patients with type 1 diabetes mellitus. Problems of Endocrinology. 2001;47(4):23-25. (In Russ.) https://doi.org/10.14341/probl11578
Views:
4663
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND 4.0).
Email this article 
.jpg){kind=logo}
