Β-cell function and insulin sensitivity in patients with type 2 diabetes mellitus
https://doi.org/10.14341/probl11580
Abstract
Beta-cell function (BCF) and insulin resistance (IR) assayed by HOMA analysis were evaluated in type 2 diabetic women with signs of the metabolic syndrome, different glycemic control, and duration of diabetes. Correlations of HOMA indices with fasting blood glucose (FBG) and serum lipid parameters (lipid profile, VLDL + LDL and HDL hydroperoxides) were estimated. Glucose and lipid metabolic parameters were studied by universal bi ochemical methods, blood insulin was measured by radioimmu noassay. There was a significant negative correlation between BCF and FBL levels. IR verified by HOMA analysis was highly associated with FBG levels and it persisted even under god gly cemic control. HOMA IR values positively correlated with lipid profiles (total cholesterol, LDL cholesterol) and lipid peroxida tion activity (VLDL + HDL hydroperoxides). The results agree with the glucotoxicity concept and validate its predominance over lipotoxicity in the genesis of beta-cell dysfunction.
About the Authors
M. Yu. GorshunskayaKharkov Medical Academy of Postgraduate Education
Ukraine
0. M. Beletskaya
Kharkov Medical Academy of Postgraduate Education
Ukraine
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For citations:
Gorshunskaya M.Yu., Beletskaya M. Β-cell function and insulin sensitivity in patients with type 2 diabetes mellitus. Problems of Endocrinology. 2003;49(3):6-9. (In Russ.) https://doi.org/10.14341/probl11580
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