The informative value of the parameters of lymphocytic enzyme activity in patients with autoimmune thyroid diseases
https://doi.org/10.14341/probl11586
Abstract
The informative value of lymphocytic metabolic enzymes in female patients with diffuse toxic goiter (DTG) and autoimmune thyroiditis (AIT) was comparatively studied. The decreased activity of enzymes (mainly a mitochondrial compartment) determining the level of aerobic respiration is a common feature of the metabolism of peripheral lymphocytes in females with DTG and AIT. The lower activity of NA D-dependent dehydrogenases of the Krebs' cycle in the lymphocytes in females with aytoimmune thyroid disease leads to an increase in the significance of the levels of malic-enzyme and NADP-dependent glutamate dehydrogenase, which was revealed by a neuronet predictor. The specific feature of the metabolism of immunocompetent cells in patients with A IT was found to have enzymatic activity changes, suggesting a decrease in the substrate current by glycosis, which is accompanied by an increase in the value of an aerobic reaction of lactate dehydrogenase (LDH) in the neuronet model. On the contrary, patients with AIT were found to have changes in a number of cytoplasmatic dehydrogenases whose altered activity stimulated the rate of glycolysis and caused an increase in the anaerobic reaction of LDH.
About the Authors
A. A. SavchenkoInstitute of Medical Problems of the North SB RAMS; Endocrinology Center at the Regional Clinical Hospital No. 1
Russian Federation
S. G. Kadricheva
Institute of Medical Problems of the North SB RAMS; Endocrinology Center at the Regional Clinical Hospital No. 1
Russian Federation
S. A. Dogadin
Institute of Medical Problems of the North SB RAMS; Endocrinology Center at the Regional Clinical Hospital No. 1
Russian Federation
A. Yu. Burakov
Institute of Medical Problems of the North SB RAMS; Endocrinology Center at the Regional Clinical Hospital No. 1
Russian Federation
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Review
For citations:
Savchenko A.A., Kadricheva S.G., Dogadin S.A., Burakov A.Yu. The informative value of the parameters of lymphocytic enzyme activity in patients with autoimmune thyroid diseases. Problems of Endocrinology. 2003;49(3):18-22. (In Russ.) https://doi.org/10.14341/probl11586
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