The effect of neuropeptides on the functional state of the endocrine function of the pancreas. Effects of chronic administration of [Arg8] vasopressin
https://doi.org/10.14341/probl11668
Abstract
Experiments on intact and diabetic rats demonstrated that 10-day injections of [Arg8]-vasopressin (intracerebroventricu- lar (icv) daily dose 24 fM, intraperitoneal (ip) 240 pM) leads to increase in insulin content in pancreatic beta-cells in nor- moglycaemic rats by 6.6 ± 0.2% in comparison with the controls and in hyperglycaemic diabetic rats by 25.6 ± 0.6% after icv injection and by 15.9 ± 0.8% after ip injection. Injection of vasopressin to diabetic animals decreased the level of glycaemia by 37% but did not affect the destruction of Langerhans’ islets. The insulin-stimulating effect of chronic icv vasopressin can be explained by modulation of the functional activity of the hypothalamic centers of feeding behavior and with the vagus nerve dorsal motor nucleus, while ip injection of the peptide directly stimulates the production of insulin in beta-cells.
About the Authors
A. V. AbramovZaporizhzhya Medical University of the Ministry of Health of Ukraine
Ukraine
Yu. M. Kolesnik
Zaporizhzhya Medical University of the Ministry of Health of Ukraine
Ukraine
S. D. Trezhetsky
Zaporizhzhya Medical University of the Ministry of Health of Ukraine
Ukraine
O. V. Gancheva
Zaporizhzhya Medical University of the Ministry of Health of Ukraine
Ukraine
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Review
For citations:
Abramov A.V., Kolesnik Yu.M., Trezhetsky S.D., Gancheva O.V. The effect of neuropeptides on the functional state of the endocrine function of the pancreas. Effects of chronic administration of [Arg8] vasopressin. Problems of Endocrinology. 1998;44(6):44-47. (In Russ.) https://doi.org/10.14341/probl11668
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