Multigormonal secretory activity of cells of clinically non-functioning pituitary tumors in vitro and the effect of tyroliberin on it
https://doi.org/10.14341/probl11705
Abstract
Experiments on cell cultures demonstrated that isolated cells of clinically inert pituitary tumors release several hormones in small amounts into the medium: luteinizing and follicle-stimulating hormones, alpha-subunit of glycoprotein hormones, prolactin, and growth hormone. Multihormonal secretion of these cells indicates their poor morphofunctional differentiation. In contrast to normal pituitary cells, cells of clinically inert pituitary tumors respond nonspeciflcally to hypothalamic thyrotropin releasing hormone: by increased secretion of prolactin, gonadotropins, glycoprotein hormone alpha-subunit, and growth hormone. This capacity of tumor cells detected in vitro agrees with the probability of increased levels of gonadotropins and glycoprotein hormone alpha-subunit in the serum of patients with clinically inert pituitary tumors during pharmacodynamic thyrotropin releasing hormone test.
About the Authors
A. A. BulatovEndocrinological Research Center of RAMS; Research Institute of Neurosurgery named after Acad. N. N. Burdenko RAMS
Russian Federation
E. E. Makarovskaya
Endocrinological Research Center of RAMS; Research Institute of Neurosurgery named after Acad. N. N. Burdenko RAMS
Russian Federation
N. B. Smirnova
Endocrinological Research Center of RAMS; Research Institute of Neurosurgery named after Acad. N. N. Burdenko RAMS
Russian Federation
V. G. Shlykova
Endocrinological Research Center of RAMS; Research Institute of Neurosurgery named after Acad. N. N. Burdenko RAMS
Russian Federation
S. Yu. Kasumova
Endocrinological Research Center of RAMS; Research Institute of Neurosurgery named after Acad. N. N. Burdenko RAMS
Russian Federation
References
1. Булатов А. А., Комолов И. С., Смирнова Н. Б. и др. // Бюл. экспер. биол. — 1992. — № 4. — С. 406—409.
2. Булатов А. А., Киселева А. Г., Горшкова Т. В., Акопова Н. Б. // Пробл. эндокринол. — 1994. — № 6. — С. 44—47.
3. Булатов А. А., Киселева А. Г., Горшкова Т. В. и др. // Вопр. мед. химии. — 1995. — № 5. — С. 19—23.
4. Булатов А. А., Мартынов А. В., Григорьян А. ГТ, Комолов И. С. Ц Биохимия. - 1995. - № 10. - С. 1637-1646.
5. Вакс В. В., Марова Е. И., Гончаров Н. П. и др. // Пробл. эндокринол. — 1997. — № 4. — С. 13—18.
6. Комолов И. С., Булатов А. А., Макаровская Е. Е. и др. // Бюл. экспер. биол. — 1994. — № И. — С. 543—546.
7. Alexander J. М., Biller В. М., Bikkal Н. et al. // J. clin. Invest. — 1990- Vol. 86. - P. 336-340.
8. Faglia G. // Eur. J. Endocrinol. - 1995. - Vol. 133. - P. 23-24.
9. Katsnelson H., Alexander J. M., Klibanski A. // J. clin. Endocrinol. Metab. - 1993. - Vol. 76. - P. 1089-1095.
10. Luizzi A., Tassi V., Pierro M. T. et al. // Metabolism. — 1996. — Vol. 45, N 8. - Suppl. 1. - P. 80-82.
11. Spcida A., Vallar L., Faglia G. // Eur. J. Endocrinol. — 1994. — Vol. 130. - P. 43-52.
Review
For citations:
Bulatov A.A., Makarovskaya E.E., Smirnova N.B., Shlykova V.G., Kasumova S.Yu. Multigormonal secretory activity of cells of clinically non-functioning pituitary tumors in vitro and the effect of tyroliberin on it. Problems of Endocrinology. 1999;45(1):40-43. (In Russ.) https://doi.org/10.14341/probl11705
Views:
692
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND 4.0).
Email this article 
.jpg){kind=logo}
