Clinical and biochemical characteristics of growth hormone receptor insufficiency (Larone’s syndrome)
https://doi.org/10.14341/probl11814
Abstract
According to reports, patients with a number exceeding 150 with growth hormone receptor deficiency (HSCI) are mainly living in the Mediterranean region, with the exception of 7 patients from the Indian subcontinent. In Israel and Ecuador, the highest population concentrations of patients with HSCG are noted. For both of these places of population concentrations, incest is typical; there are also reports of a similar phenomenon in sporadic cases from other places. As with any hereditary disorders, apparently, in this condition there is both wide genetic heterogeneity and variable phenotypic expression.
About the Authors
A RosenblomFlorida University, USA; St Bartholomew's Hospital, London, Breat Britain; University children's hospital, Tuebingen, Germany; Endocrinology, metabolism and reproduction institute, Quito, Ecuador; Stanford University, USA
United States
M Savage
Florida University, USA; St Bartholomew's Hospital, London, Breat Britain; University children's hospital, Tuebingen, Germany; Endocrinology, metabolism and reproduction institute, Quito, Ecuador; Stanford University, USA
United States
U Bloom
Florida University, USA; St Bartholomew's Hospital, London, Breat Britain; University children's hospital, Tuebingen, Germany; Endocrinology, metabolism and reproduction institute, Quito, Ecuador; Stanford University, USA
United States
H Gevara-Aguirre
Florida University, USA; St Bartholomew's Hospital, London, Breat Britain; University children's hospital, Tuebingen, Germany; Endocrinology, metabolism and reproduction institute, Quito, Ecuador; Stanford University, USA
United States
R Rosenfeld
Florida University, USA; St Bartholomew's Hospital, London, Breat Britain; University children's hospital, Tuebingen, Germany; Endocrinology, metabolism and reproduction institute, Quito, Ecuador; Stanford University, USA
United States
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Review
For citations:
Rosenblom A., Savage M., Bloom U., Gevara-Aguirre H., Rosenfeld R. Clinical and biochemical characteristics of growth hormone receptor insufficiency (Larone’s syndrome). Problems of Endocrinology. 1994;40(2):74-77. (In Russ.) https://doi.org/10.14341/probl11814
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