Early and long-term neuroendocrine effects of prenatal stress in male and female rats
https://doi.org/10.14341/probl11833
Abstract
The effect of maternal stress or so-called prenatal stress (PS) on the neuroendocrine regulation of reproduction and stress reactivity of the progeny was studied. Prenatal stress prevented the formation of sex dimorphism of catecholamine content and aromatase and androgen 5a-reductase activities in the preoptic region of the brain and mediobasal hypothalamus of 10-day-old rats. Leveling of sex-specific differences in the size of the neurocyte nuclei in the suprachiasmatic nucleus was the morphological equivalent of functional disorders induced by PS. Stress and adrenergic reactivity of the hypothalamo-pituitary-adrenal system was changed in prenatally stressed males and females. Remote effects of PS are regarded as a manifestation of disorders in the hormone neurotransmitter imprinting of the neuroendocrine system.
Supporting agencies: This work was supported by the International Science Foundation J. Soros (grants UAP000 and UAP200).
About the Authors
A. G. ReznikovInstitute of Endocrinology and Metabolism V.P. Komissarenko of the Academy of Medical Sciences of Ukraine
Ukraine
N. D. Nosenko
Institute of Endocrinology and Metabolism V.P. Komissarenko of the Academy of Medical Sciences of Ukraine
Ukraine
L. V. Tarasenko
Institute of Endocrinology and Metabolism V.P. Komissarenko of the Academy of Medical Sciences of Ukraine
Ukraine
P. V. Sinitsyn
Institute of Endocrinology and Metabolism V.P. Komissarenko of the Academy of Medical Sciences of Ukraine
Ukraine
L. I. Polyakova
Institute of Endocrinology and Metabolism V.P. Komissarenko of the Academy of Medical Sciences of Ukraine
Ukraine
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Review
For citations:
Reznikov A.G., Nosenko N.D., Tarasenko L.V., Sinitsyn P.V., Polyakova L.I. Early and long-term neuroendocrine effects of prenatal stress in male and female rats. Problems of Endocrinology. 2000;46(1):30-34. (In Russ.) https://doi.org/10.14341/probl11833
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