Intrathyroid content of iodine and thyroid function in diffuse nontoxic goiter

The ultrasonic picture and volume of the thyroid, concentrations of intrathyroid stable iodine, total amount of stable iodine, scintigraphy of the organ, blood concentrations of basal TTH, fгее T4 and T3, antibodies to thyroglobulin, and microsomal fraction were studied in 77 patients (69 women and 8 men) with diffuse nontoxic goiter and 37 controls (18 women and 19 men) aged 18 to 50 without enlargement or signs of impairment of the function of the thyroid. Diffuse nontoxic goiter was found to be associated with increase of the thyroid volume, concentrations of intrathyroid stable iodine and total amount of stable iodine, and TTH, and a decreased concentration of T4. A deficit of intrathyroid stable iodine and of T3 in the blood was revealed in 20% of women with antibodies to thyroglobulin and microsomal fraction in the blood, in comparison with patients who had no antibodies to thyroglobulin and microsomal fraction. A reduced concentration of intrathyroid stable iodine in control women was attended by the presence of antibodies to thyroglobulin and/or microsomal fraction and indirect ultrasonic signs of autoimmune pathology of the thyroid. These results permit a conclusion that iodine measurements directly in the thyroid using noninvasive x-ray fluorescent analysis is a sensitive and informative additional method for the diagnosis of thyroid abnormalities.

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