Activities of membranebound proteinkinase c and red cell ATPases in diabetic angiopathy
https://doi.org/10.14341/probl11896
Abstract
The activities of proteinkinase C, total, Mg2 and Na+, K+-dependent ATPases in red cell membranes were compared in 46 patients with insulin independent, 30 ones with insulin dependent diabetes mellitus with various degrees of vascular disorders, and in 17 patients with atherosclerosis with the predominant involvement of the main vessels of the lower limbs. Diabetes mellitus and the progress of vascular disorders were associated with a more marked depression of proteinkinase C, total and Na+, K+-dependent ATPase activities, this being particularly characteristic of the patients with insulin-independent diabetes and macrovascular disorders, inhibited activities of proteinkinase C and ATPases in red cell membranes in the course of diabetic vascular disorders progress evidence their contribution to the pathogenesis of diabetic angiopathy.
About the Authors
A. S. YefimovKyiv research Institute of endocrinology and metabolism; Lvov medical Institute
Ukraine
A. A. Serghiyenko
Kyiv research Institute of endocrinology and metabolism; Lvov medical Institute
Ukraine
Z. D. Vorobets
Kyiv research Institute of endocrinology and metabolism; Lvov medical Institute
Ukraine
L. M. Serghiyenko
Kyiv research Institute of endocrinology and metabolism; Lvov medical Institute
Ukraine
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Review
For citations:
Yefimov A.S., Serghiyenko A.A., Vorobets Z.D., Serghiyenko L.M. Activities of membranebound proteinkinase c and red cell ATPases in diabetic angiopathy. Problems of Endocrinology. 1993;39(1):11-14. (In Russ.) https://doi.org/10.14341/probl11896
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