Niftolide tests used in the diagnosis of male hypogonadism
https://doi.org/10.14341/probl11958
Abstract
Comparative analysis with an antiandrogen niftolide and synthetic GnRF was carried out in 22 normal subjects, 14 patients with primary and 20 ones with secondary hypogonadism, and in 5 patients with clinical signs of gonadal insufficiency and obscure diagnosis in order to elucidate the pituitary gonadotropin reserves. Blood plasma and daily urine gonadotropin levels were measured. Changed gonadotropin excretion under the effect of niftolide in health and hypogonadism was in line with changed gonadotropin level in the blood after RF administration, this indicating a similar informative value of both tests for the differential diagnosis of various hypogonadism forms. In the first case measurements of blood gonadotropin were more informative, in the second daily urine analysis. Niftolide test, noninvasive and readily available, is recommended as an alternative test with RF administration.
About the Authors
A. G. ReznikovV.P. Komisarenko Institute of Endocrinology and Metabolism
Ukraine
S. V. Varga
V.P. Komisarenko Institute of Endocrinology and Metabolism
Ukraine
V. N. Demchenko
V.P. Komisarenko Institute of Endocrinology and Metabolism
Ukraine
O. Ya. Boyarskaya
V.P. Komisarenko Institute of Endocrinology and Metabolism
Ukraine
References
1. Веникова Е. А., Резников А. Г., Златник А. А., Демченко В. Н. Способ дифференциальной диагностики вторичного гипогонадизма и задержанного полового развития. А. с. 124946 СССР // Открытия,- 1986.- № 29.
2. Веникова Е. А., Резников А. Г., Златник А. А., Демченко В. И. Функциональная проба с хорионическим гонадотропином в дифференциальной диагностике задержанного полового развития и гипогонадизма у лиц мужского пола: Информ. письмо.- Киев, 1987.- Вып. 1.
3. Резников А. Г., Демченко В. Н., Ягупольский Л. М. и др. А. с. 552962 СССР // Открытия.- 1977.- № 13.- С. 15.
4. Резников А. Г., Веникова Е. А., Демченко В. Н. // Радиолог, журн.- 1978.- № 5.- С. 687-691.
5. Резников А. Г., Варга С. В., Веникова Е. А. и др. // Пробл. эндокрииол.- 1985.- № 2.- С. 15-18.
6. Резников А. Г., Варга С. В., Боярская О. Я. и др. // Там же.- № 3.- С. 26-29.
7. Скородок Л. М., Савченко О. И. Нарушение полового развития у мальчиков.- М., 1984.
8. Amendt Р. // Padiat. u. Crenzgeb.- 1988,- Bd 27, N 3.- £
9. Freischem С. W., Melms R., Niechlag E. // Acta endocr. (Kbh.).- 1985,- Vol. 99, Suppl. 246,- P. 9-12.
10. Gossage A., Punnan S. // Postgrad, med. J.- 1985.- Vol. 61, N 7,- P. 195-200.
11. Patrisch C. J., Hermanussen M., Sipple W. // J. clin. Endocr.- 1985,- Vol. 60, N 6,- P. 1196-1203.
12. Wide L., Gemrell C. // Acta endocr. (Kbh.).- 1961.- Vol. 37.- P. 445-449.
Review
For citations:
Reznikov A.G., Varga S.V., Demchenko V.N., Boyarskaya O.Ya. Niftolide tests used in the diagnosis of male hypogonadism. Problems of Endocrinology. 1993;39(5):28-31. (In Russ.) https://doi.org/10.14341/probl11958

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND 4.0).