Effect of a-tocopherol on the development of diabetic angiopathy, platelet aggregation, and prostacyclin-thromboxan system of rats with streptozotocin-induced diabetes
https://doi.org/10.14341/probl11988
Abstract
Under study were effects of intravenous infusions of a new emulsion, α-tocopherol, on the development of diabetic microangiopathy, platelet α-tocopherol level, ADP-induced platelet aggregation level, exogenic (from 14C-arachidonic acid) thromboxan (TxA2) biosynthesis in suspension of washed platelets and of prostacyclin (Pgb) one in isolated aortic rings of rats with streptozotocin-induced diabetes. Six-week injections of α-tocopherol in a dose 100 mg/100 g b. w. with 48 h intervals immediately after development of streptozotocin-induced diabetes prevented the development of diabetic angiopathy but did not normalize platelet functional activity and Pgl2/TxA2 balance in vessels and platelets. Similar injections of α-tocopherol in the presence of developed angiopathy resulted in its regressive development and normalization of the before-said prostanoid balance and platelet characteristics.
About the Authors
G. F. Zadkova
Research Institute of Pediatrics, RAMS
Russian Federation
Russian Federation
T. Yu. Avakyan
Research Institute of Pediatrics, RAMS
Russian Federation
Russian Federation
Kh. M. Markov
Research Institute of Pediatrics, RAMS
Russian Federation
Russian Federation
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Review
For citations:
Zadkova G.F., Avakyan T.Yu., Markov Kh.M. Effect of a-tocopherol on the development of diabetic angiopathy, platelet aggregation, and prostacyclin-thromboxan system of rats with streptozotocin-induced diabetes. Problems of Endocrinology. 1993;39(5):40-43. (In Russ.) https://doi.org/10.14341/probl11988
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