Growth hormone level during stimulation test and efficacy of growth hormone therapy of idiopathically undersized children with this hormone insufficiency

For the first time, a broad study of the effectiveness of treatment with growth hormone (GH) in patients with varying degrees of impaired secretion of GH is undertaken. In this work, 885 patients of pre-pubertal age who received treatment for 1 year were examined. All children were given 2 standard tests with stimulation of the secretion of GH. The following diagnoses were established: idiopathic insufficiency of GH (classification number 1.1) or idiopathic stunting (3.1). Patients were divided into groups depending on the maximum release of GH during sampling: A - in both samples <5 ng/ml, B - in one sample <5 ng/ml, in another - 5-10 ng/ml, C - in both samples 5-10 ng/ml, D - in one sample 5-10 ng/ml, in another - >10 ng/ml, E - in both samples >10 ng/ml.anthropometric indicators, main parameters of therapy and results of treatment of GY were evaluated in all developed model (expected RESULTS). According to the study, patients with the most severe GH deficiency (group A) had better treatment outcomes, while the other groups were almost identical. The division of group A into a subgroup with isolated GH deficiency and a subgroup with deficiency of other tropic hormones (hypopituitarism) showed that in the first subgroup the growth of parents was significantly lower. Thus, despite the fact that standard samples with stimulation of GH can be used to diagnose the insufficiency of GH, the results of these samples do not always allow to predict the effectiveness of treatment of GH for 1 year. It should also be noted that the shortness of the parents, especially the growth of the mother, may indicate the presence of an additional hereditary factor in the Genesis of shortness in these patients.

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