Insulin and adrenalin effects on the activity and concentration of glutathione metabolizing enzymes in rat organs
https://doi.org/10.14341/probl12015
Abstract
Adrenaline activates glutathione peroxidase in the heart, liver, and kidneys and glutathione transferase in the heart and liver, inhibits gamma-glutamyl transferase in the kidneys, and has no effect on glutathione reductase; no changes in the brain detected. Insulin does not influence glutathione reductase either, nor does it induce any changes in the heart, liver, and bone marrow, but it alters (as a rule reduces) in a number of cases the activities of many glutathione metabolism enzymes and reduces glutathione concentration in the brain, kidneys, and spleen both an hour and 24 h after injection. The detected changes do not conform to universally acknowledged classification of the organs by insulin sensitivity and do not correlate with hypoglycemia.
About the Authors
L. S. Kolesnichenko
Irkutsk Medical Institute
Russian Federation
Russian Federation
V. I. Kulinsky
Irkutsk Medical Institute
Russian Federation
Russian Federation
M. V. Yasko
Irkutsk Medical Institute
Russian Federation
Russian Federation
G. A. Pensionerova
Irkutsk Medical Institute
Russian Federation
Russian Federation
Yu. V. Grudinina
Irkutsk Medical Institute
Russian Federation
Russian Federation
References
1. Кендыш И. Н. // Регуляция углеводного обмена.— М., 1985,— С. 41—75; 128—131.
2. Колесниченко Л. С., Манторова Н. С., Шапиро Л. А. // Биохимия,— 1987,— Т. 52, № 5.— С. 743—749.
3. Колесниченко Л. С., Кулинский В. И., Манторова Н. С., Шапиро Л. А. // Физиол. журн. СССР.— 1990.— Т. 76, № 10,— С. 1418—1425.
4. Кулинский В. И., Колесниченко Л. С. // Успехи биол. химии,— 1990,— Т. 31,— С. 157—179.
5. Мертвецов Н. П. // Гормональная регуляция экспрессии генов / Под ред. В. И. Кулинского.— М., 1986.— С. 47—57.
6. Теппермен Дж., Теппермен X. // Физиология обмена веществ и эндокринной системы: Пер. с англ.— М., 1989.— С. 458—492.
7. Anderson М. Е. // Glutathione: Chemical, Biochemical and Medical Aspects / Eds D. Dolphin et al.— New York, 1989,— Pt A.— P. 333—405.
8. Carnovale С. E., Monti J. A., Catania V. A., Carillo M. C. // Canad. J. Physiol. Pharmacol.— 1990,— Vol. 68, N 2.— P. 170-173.
9. Denton R. M. 11 Advanc. Cyclic Nucleotide Protein Phosphorylat. Res.— 1986.— Vol. 20.— P. 293—341.
10. Pilkis E. J., El-Mashrabi M. R. // Ann. Rev. Biochem.— 1988,— Vol. 57.— P. 755—783.
11. Shirmer R. H., Krauth-Siegel R. L. // Glutathione: Chemical, Biochemical and Medical Aspects / Eds D. Dolphin et al.— New York, 1989.— Pt A.— P. 553—596.
12. Taniguchi H., Pyerin IT. // Biochem. biophys. Res. Commun.— 1989.— Vol. 162, N 3.— P. 903—907.
Review
For citations:
Kolesnichenko L.S., Kulinsky V.I., Yasko M.V., Pensionerova G.A., Grudinina Yu.V. Insulin and adrenalin effects on the activity and concentration of glutathione metabolizing enzymes in rat organs. Problems of Endocrinology. 1994;40(3):42-44. (In Russ.) https://doi.org/10.14341/probl12015
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