Somatotropic insufficiency in children and antip1tu1tary antibodies as characteristics of humoral immunity in patients and their parents
https://doi.org/10.14341/probl12035
Abstract
Antibodies to adeno-pituitary cell surface antigen (PCSA) were studied in 40 untreated children with idiopathic growth hormone (GH) deficiency to elucidate the role of autoimmune disorders in the pathogenesis of GH deficiency. Antibodies to rat PCSA were assayed by ELISA. PCSA was detected in 15% of patients with GH deficiency, in contrast to that in healthy children and children with autoimmune thyroid diseases. The authors consider that in some cases GH deficiency may be caused by autoimmune hypophysitis. A family study revealed PCSA in 25% of mothers of patients with GH deficiency. In a population of healthy women PCSA was detected in 5.7% cases. Hence, a hereditary background of autoimmune abnormality cannot be completely ruled out.
About the Authors
O. V. Fofanova
Endocrinology Research Centre
Russian Federation
Russian Federation
V. A. Peterkova
Endocrinology Research Centre
Russian Federation
Russian Federation
I. V. Kryukova
Endocrinology Research Centre
Russian Federation
Russian Federation
Yu. M. Keda
Endocrinology Research Centre
Russian Federation
Russian Federation
V. I. Kandror
Endocrinology Research Centre
Russian Federation
Russian Federation
A. A. Bulatov
Endocrinology Research Centre
Russian Federation
Russian Federation
N. P. Goncharov
Endocrinology Research Centre
Russian Federation
Russian Federation
T. A. Osipova
Endocrinology Research Centre
Russian Federation
Russian Federation
G. P. Yelizarova
Endocrinology Research Centre
Russian Federation
Russian Federation
Yu. A. Pankov
Endocrinology Research Centre
Russian Federation
Russian Federation
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Review
For citations:
Fofanova O.V., Peterkova V.A., Kryukova I.V., Keda Yu.M., Kandror V.I., Bulatov A.A., Goncharov N.P., Osipova T.A., Yelizarova G.P., Pankov Yu.A. Somatotropic insufficiency in children and antip1tu1tary antibodies as characteristics of humoral immunity in patients and their parents. Problems of Endocrinology. 1996;42(3):10-15. (In Russ.) https://doi.org/10.14341/probl12035
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