Lipid metabolism and hormonal status in patients with type I diabetes mellitus combined with subclinical hypothyroidism

Abstract

Lipid metabolism and thyroid hormonal status were examined in diabetics with type 1 condition, subclinical hypothyroidism, and a combination of both. Lipid spectrum of the blood was assessed: total cholesterol, b-lipoproteins, triglycerides, a-cholesterol, total lipids, atherogenicity index, as well as the pituitary thyrotropic hormone, triiodothyronine, and thyroxin. Hyperlipoproteinemia was detected, which was particularly typical of atherogenic lipids in not only adult patients with type I diabetes, but in children as well, paralleled by an increase of the blood level of the pituitary thyrotropic hormone possessing a lipolytic activity. Atherogenic disorders in the lipid spectrum of children with subclinical hypothyroidism presenting as dyslipoproteinemia are considered to anticipate hyperlipoproteinemia in adult patients. A subclinical hypofunction of the thyroid is conducive to disorders of lipid metabolism when combined with type I diabetes and to boosting the atherosclerotic involvement of the vessels in children.