Enzymuria in diabetics with type ii condition and disordered purine metabolism

Abstract

The authors compare enzymuria occurring in disorders of purine metabolism in patients with types I and II diabetes. Urinary enzymes (alkaline phosphatase, lactate dehydrogenase, N-acetyl-b-D-glucosaminidase, alanine aminopeptidase, cholinesterase, and b-galactosidase) were measured in 25 patients with noninsulin-dependent (NIDDM) and insulin-dependent diabetes mellitus (IDDM) with different disorders of purine metabolism (hyperuricemia and hyperuricosuria) and in 27 normal controls. The study revealed the syndrome of enzymatic insufficiency and syndrome of increased glomerular permeability (expressed increase of cholinesterase level in the urine) in patients with NIDDM; the latter syndrome was expressed similarly in patients with both NIDDM and IDDM. This syndrome was particularly severe in patients with IDDM complicated by diabetic nephropathy and disordered purine metabolism.