Thyroid function of rats kept on increased iodine diet fed with drinking water
https://doi.org/10.14341/probl12195
Abstract
Thyroid and adrenocortical function was examined in rats fed increasing quantities of iodine with drinking water. No noticeable deviations in thyroid hormone levels were found in the blood of experimental animals. Thyroid hormone levels in thyroid tissue were changing in the same direction in the animals kept on various iodine diets, these changes depending on experiment duration: an increase of thyroxine and more so, of triiodothyronine was observed in 50 days, and reduction thereof in 90 days. In rats fed the maximal iodine dose, 8000 mcg daily, the level of thyroglobulin in thyroid tissue decreased. Increased iodine consumption reduced the glucocorticoid function of the adrenals in experimental animals, this manifesting by reduction of corticosterone level in the adrenals, blood plasma, and reduction of non-metabolized hormone excretion with the urine.
About the Authors
V. G. Selyatitskaya
Institute of General Pathology and Human Ecology
Russian Federation
Russian Federation
N. A. Palchikova
Institute of General Pathology and Human Ecology
Russian Federation
Russian Federation
S. V. Odintsov
Institute of General Pathology and Human Ecology
Russian Federation
Russian Federation
References
1. Данн Дж. Т. // Ликвидация заболеваний, связанных с дефицитом йода: Материалы международного симпозиума. — Ташкент, 1991.— С. 69—74.
2. Дедов И.И., Юденич О.Н., Герасимов Г.А., Смирнов Н.Г. // Пробл. эндокринол. — 1992. — Т. 38. № 3. — С. 6—15.
3. Де Мейер Е.М., Лоуенстейн Ф.У., Тийи К.Г. Борьба с эндемическим зобом. — Женева, 1981.
4. Мышкина А.К. Механизмы гомеостатического контроля в щитовидной железе. — Саратов, 1989.
5. Силаева С.В., Самохин В.Т., Башкеев Е.Д., Фомичев Ю.П. // Ветеринария. — 1970. — № 6. — С. 97—98.
6. Сукманский О.И., Барабаш Р.Д., Фомин В.В. // Физиология и патология пищеварения. — Кишинев, 1972. — С. 183— 184.
7. Туракулов Я.Х. Обмен йода и тиреоидные гормоны. — Ташкент, 1959.
8. Bravermann L.E. // Acta med. auslr. — 1990. — Vol. 17, N 1. - P. 29-33.
9. Distefano J.J., Sapin V. // Endocrinology. — 1987. — Vol. 121, N 5. - P. 1742-1750.
10. Kamilaris T.C., De Bold C.R., Johnson E.O. et al. // Ibid. — 1991. - Vol. 128, N 3. - P. 2567-2576.
11. Nagataki S., Yokoyama N. // Acta med. austr. — 1990,— Vol. 17, N 1. - P. 4-8.
12. Nagataki S., Morita S. // Asian med. J. — 1991. — Vol. 34, N 2. - P. 77-82.
13. Rutgers M., Heusdens F.A., Bonthuis F. et al. // Endocrinology. - 1989. — Vol. 125, N 6. - P. 2822-2830.
14. Sherer T.T., Thrall K.D., Bull R.J. // J. Toxicol, environm. Hlth. — 1991. — Vol. 32, N 1. - P. 89-101.
15. Wang X., Jan J., Li J. // New Era Global Harmony and Nutrition: Proceedings of the 14-th International Congress Nutrition. - Seoul, 1989. - Vol. 1. - P. 822-825.
Review
For citations:
Selyatitskaya V.G., Palchikova N.A., Odintsov S.V. Thyroid function of rats kept on increased iodine diet fed with drinking water. Problems of Endocrinology. 1994;40(6):50-53. (In Russ.) https://doi.org/10.14341/probl12195
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