Effects of hypothalamic mediator systems on the hormonal changes in rabbit blood during prolonged electric stimulation of emotiogenic zones of the hypothalamus
https://doi.org/10.14341/probl12196
Abstract
Changes in the blood hormonal levels were studied In 36 rabbits with electrodes implanted to the area of the dorsomedial nuclei of the hypothalamus in the course of a 5-cycle electrostimulation experiment. After each period blood hormonal levels were correlated to the activities of the hypothalamic catecholamino-, GABA-, and serotoninergic systems. The first two cycles of the experiment were associated with a high activity of the hypothalamic mediator systems and with increased levels of all hormones in the blood. The functional activity of the hypothalamus was reduced due to the predominance of stress-limiting systems. The initial reduction of GABA, and then of serotonin in the hypothalamus caused be the end of experiment a reduction of the blood levels of the tested hormones, except the Ca-regulating ones and active renin. Disturbances in the regulatory mechanisms of hypothalamic mediator systems leads to an increase in its excitability and to transformation of the adaptive pattern of hormonal changes into pathological mechanisms of prolonged emotional stress.
About the Authors
V. I. Nikolayev
Saint Petersburg State Public Health Medical Institute
Russian Federation
Russian Federation
Ye. Yu. Gornushkina
Saint Petersburg State Public Health Medical Institute
Russian Federation
Russian Federation
A. A. Nikolayeva
Saint Petersburg State Public Health Medical Institute
Russian Federation
Russian Federation
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Review
For citations:
Nikolayev V.I., Gornushkina Ye.Yu., Nikolayeva A.A. Effects of hypothalamic mediator systems on the hormonal changes in rabbit blood during prolonged electric stimulation of emotiogenic zones of the hypothalamus. Problems of Endocrinology. 1994;40(6):53-56. (In Russ.) https://doi.org/10.14341/probl12196
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