Differential diagnosis of normocalcemic hyperparathyroidism and idiopathic hypercalciuria on the example of clinical case
https://doi.org/10.14341/probl12677
Abstract
Idiopathic hypercalciuria is a heterogeneous generalized disorder caused by various defects in calcium transport and increased urinary calcium excretion. The main etiopathogenetic factors are violations of vitamin D metabolism, changes in the sensitivity of calcitriol receptors and violations of the processes of calcium reabsorption in the proximal tubules and in the ascending knee of the Henle loop. This article presents a clinical observation of patient with idiopathic hypercalciuria, initially high levels of parathyroid hormone (PTH) in the absence of hyperparathyroidism. Therapy with thiazide diuretics allowed to achieve normalization of daily urinary calcium excretion and reducing PTH. Despite the low prevalence of idiopathic hypercalciuria, differential diagnosis of this metabolic disorder should be carried out with mandatory consideration of clinical and laboratory data, as well as with diseases that may cause increased PTH production.
About the Authors
G. E. Runova
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation
Competing Interests: No
Russian Federation
Gyuzel E. Runova - MD, PhD.
8-2 Trubetskaya street, 119991 Moscow.
eLibrary SPIN: 3639-6932
Competing Interests: No
O. O. Golounina
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation
Competing Interests: No
Russian Federation
Olga O. Golounina - Student, Medical faculty.
8-2 Trubetskaya street, 119991 Moscow.
eLibrary SPIN: 7793-2123
Competing Interests: No
I. V. Glinkina
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation
Competing Interests: No
Russian Federation
Irina V. Glinkina - MD, PhD.
8-2 Trubetskaya street, 119991 Moscow.
eLibrary SPIN: 2731-2400
Competing Interests: No
Yu. P. Sych
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation
Competing Interests: No
Russian Federation
Yulia P. Sych - MD, PhD.
8-2 Trubetskaya street, 119991 Moscow.
eLibrary SPIN: 3406-0978
Competing Interests: No
V. V. Fadeev
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation
Competing Interests: No
Russian Federation
Valentin V. Fadeyev - MD, PhD, Professor.
8-2 Trubetskaya street, 119991 Moscow.
eLibrary SPIN: 6825-8417
Competing Interests: No
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1. Figure 1. Ultrasound examination of the parathyroid glands of patient M. Description: Hyperplasia of the left lower parathyroid gland. The echographic structure of the gland is not changed. | |
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For citations:
Runova G.E., Golounina O.O., Glinkina I.V., Sych Yu.P., Fadeev V.V. Differential diagnosis of normocalcemic hyperparathyroidism and idiopathic hypercalciuria on the example of clinical case. Problems of Endocrinology. 2020;66(6):13-17. (In Russ.) https://doi.org/10.14341/probl12677
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