Prolactin-releasing peptide increases rat anxiety
https://doi.org/10.14341/probl12770
Abstract
BACKGROUND: Prolactin-releasing peptide(Prl-RP), in addition to stimulating the production of prolactin, interacts with various parts of the central nervous system, participating in the implementation of many functions that are reflected in behavior.
AIM: The effect of Prl-RP on the anxiety of white Wistar rats was studied since there were no data in the literature on the relationship between Prl-RP and anxiety.
MATERIALS AND METHODS: Anxiety was assessed in two tests. In the elevated plus-maze (EPM), the time spent in the open arms and the number of edge reactions were recorded. In the social preference test, the time spent near a stranger, near a familiar individual, and in neutral territory were recorded.
RESULTS: The administration of Prl-RP at a dose of 10-10 M with a volume of 10 µl in each nostril reduced the time spent by the animals in the open arms of the EPM, and the number of edge reactions. For testing the social interaction, animals were pre-selected for high or low levels of anxiety in the EPM. In rats with initially low levels of anxiety, Prl-RP reduced the time spent near a stranger, indicating an increase in anxiety levels. The behavior of rats with initially high levels of anxiety did not change after application of the Prl-RP.
CONCLUSION: The results of our experiments indicate that the intranasal administration of Prl-RP increases the anxiety of rats.
About the Authors
D. A. Zhukov
Pavlov Institute of Physiology RAS
Russian Federation
Competing Interests:
Russian Federation
Dmitry A. Zhukov – PhD.
6 Makarova, 199034, St-Petersburg.
eLibrary SPIN: 1416-0551
Competing Interests:
No conflict of interest.
A. G. Markov
Biological Faculty, SPb State University
Russian Federation
Competing Interests:
Russian Federation
Alexander G. Markov – PhD.
St-Petersburg.
eLibrary SPIN: 4985-0808
Competing Interests:
No conflict of interest.
E. P. Vinogradova
Biological Faculty, SPb State University
Russian Federation
Competing Interests:
Russian Federation
Ekaterina P. Vinogradova – PhD.
St-Petersburg.
eLibrary SPIN: 4899-1537
Competing Interests:
No conflict of interest.
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For citations:
Zhukov D.A., Markov A.G., Vinogradova E.P. Prolactin-releasing peptide increases rat anxiety. Problems of Endocrinology. 2021;67(5):29-33. (In Russ.) https://doi.org/10.14341/probl12770
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