Sporadic primary hyperparathyroidism with multiple parathyroid adenomas
https://doi.org/10.14341/probl12798
Abstract
Multiple lesions of the parathyroid glands (PTG) in primary hyperparathyroidism (PHPT) can be sporadic or develop as part of hereditary syndromes, manifesting at young age. There the description of a severe sporadic PHPT with big parathyroid neoplasms in the young patient is presented. Clinical data made it possible to suspect MEN-1 syndrome or parathyroid carcinomas; however, mutations CDKN, CDC73, MEN1 were excluded. The patient underwent removal of three identified tumors: benign adenomas of the left PTG and hyperplasia of the right one. Postoperative hypocalcemia and severe hungry bone syndrome required the administration of vitamin D and calcium carbonate preparations. However, a year after the operation, a «mild» recurrent disease was confirmed. Taking into account the patient’s refusal to reoperation and a significant improvement of the target organs state, active observation was continued. The patient needs further careful dynamic monitoring by specialists in order to timely identify indications for repeated surgical treatment to improve the life quality and span.
About the Authors
E. E. Bibik
Endocrinology Research Centre
Russian Federation
Russian Federation
Ekaterina E. Bibik, MD
11 Dm. Ulyanova street, 117036 Moscow
eLibrary SPIN: 8522-9466
A. K. Eremkina
Endocrinology Research Centre
Russian Federation
Russian Federation
Anna K. Eremkina, MD, PhD
Moscow
eLibrary SPIN: 8848-2660
O. A. Knyazeva
“Altamed plus”
Russian Federation
Russian Federation
Olga A. Knyazeva, MD
Odintsovo
eLibrary SPIN: 8204-0804
N. G. Mokrysheva
Endocrinology Research Centre
Russian Federation
Russian Federation
Natalia G. Mokrysheva, MD, PhD, Professor
Moscow
eLibrary SPIN: 5624-3875
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Supplementary files
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1. Рисунок 1. Мультиспиральная компьютерная томография шеи и верхнего средостения пациентки С. с контрастированием (белой стрелкой указана деформация правой ключицы, красной стрелкой — образование левой околощитовидной железы). | |
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2. Рисунок 2. Однофотонная эмиссионная компьютерная томография пациентки С. | |
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3. Рисунок 3. Диффузионная магнитно-резонансная томография шеи (красными стрелками указаны образования правой и левых околощитовидных желез). | |
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Review
For citations:
Bibik E.E., Eremkina A.K., Knyazeva O.A., Mokrysheva N.G. Sporadic primary hyperparathyroidism with multiple parathyroid adenomas. Problems of Endocrinology. 2021;67(6):31-38. (In Russ.) https://doi.org/10.14341/probl12798
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