The dual role of the menopausal hormonal therapy as the enhancer of pleiotropic telomere rejuvenation and the silencer of cellular aging (literature review)
O. R. Grigoryan,
T. M. Frolova,
R. K. Mikheev,
E. V. Sheremetyeva,
Yu. S. Absatarova,
Z. A. Uzhegova,
E. N. Andreeva,
N. G. Mokrysheva https://doi.org/10.14341/probl12895
Abstract
Present worldwide healthcare researches prove that female patients are more sensitive to the population aging. Menopause or climacteria (climax) — is not as ageing itself, but a physiological unstoppable process. The main task for a physician is to improve life quality for female despite of ageing problems. Menopausal hormone therapy (MHT) due to the estrogen component has an anti-inflammatory, antioxidant effect and promotes the expression of telomerase, which together changes the homeostasis and integrity of telomeres. The use of MHT for five years or more can not only significantly change the quality of life, but also increase its duration. Literature search was carried out in national (eLibrary, CyberLeninka.ru) and international (PubMed, Cochrane Library) databases in Russian and English. The priority was free access to the full text of articles. The choice of sources was prioritized for the period from 2019 to 2021. However, taking into account the insufficient knowledge of the chosen topic, the choice of sources dates back to 1989.
About the Authors
O. R. Grigoryan
Endocrinology Research Centre
Russian Federation
Russian Federation
Olga R. Grigoryan, MD, PhD
11 Dm. Ulyanova street, 117036 Moscow
T. M. Frolova
Endocrinology Research Centre
Russian Federation
Russian Federation
Tatyana M. Frolova, MD, resident
11 Dm. Ulyanova street, 117036 Moscow
R. K. Mikheev
Endocrinology Research Centre
Russian Federation
Russian Federation
Robert K. Mikheev, MD, resident
11 Dm. Ulyanova street, 117036 Moscow
E. V. Sheremetyeva
Endocrinology Research Centre
Russian Federation
Russian Federation
Ekaterina V. Sheremetyeva, MD, PhD
11 Dm. Ulyanova street, 117036 Moscow
Yu. S. Absatarova
Endocrinology Research Centre
Russian Federation
Russian Federation
Yuliya S. Absatarova, MD, PhD
11 Dm. Ulyanova street, 117036 Moscow
Z. A. Uzhegova
Endocrinology Research Centre
Russian Federation
Russian Federation
Zhanna A. Uzhegova, MD, PhD
11 Dm. Ulyanova street, 117036 Moscow
E. N. Andreeva
Endocrinology Research Centre; A.I. Evdokimov Moscow State University of Medicine and Dentistry
Russian Federation
Russian Federation
Elena N. Andreeva, MD, PhD
11 Dm. Ulyanova street, 117036 Moscow
N. G. Mokrysheva
Endocrinology Research Centre
Russian Federation
Russian Federation
Natalia G. Mokrysheva, MD, PhD
11 Dm. Ulyanova street, 117036 Moscow
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Grigoryan O.R., Frolova T.M., Mikheev R.K., Sheremetyeva E.V., Absatarova Yu.S., Uzhegova Z.A., Andreeva E.N., Mokrysheva N.G. The dual role of the menopausal hormonal therapy as the enhancer of pleiotropic telomere rejuvenation and the silencer of cellular aging (literature review). Problems of Endocrinology. 2022;68(3):105-112. (In Russ.) https://doi.org/10.14341/probl12895
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