Development of sarcoidosis after successful treatment of Cushing’s disease
https://doi.org/10.14341/probl13203
Abstract
Cushing’s disease is a rare severe neuroendocrine disorder caused by chronic overproduction of adrenocorticotropic hormone by a pituitary tumor. Supraphysiological concentrations of cortisol in endogenous hypercortisolism have an immunosuppressive and anti-inflammatory effect similar to therapy with systemic glucocorticosteroids. This may reduce the activity of the patient’s concomitant autoimmune inflammatory diseases. On the other hand, a decrease in cortisol levels during treatment for Cushing’s disease may be associated with a reactivation of the immune system that pose a risk of onset or recurrence of an autoimmune disorder. We present our own clinical case demonstrating the development of sarcoidosis after surgical treatment of Cushing’s disease.
About the Authors
P. A. Zakharova
Moscow Regional Research and Clinical Institute named after M.F. Vladimirsky
Russian Federation
Competing Interests:
Russian Federation
Polina A. Zakharova, MD.
str. Shchepkina 61/2, building 1, Moscow
Competing Interests:
none
I. A. Ilovayskaya
Moscow Regional Research and Clinical Institute named after M.F. Vladimirsky
Russian Federation
Competing Interests:
Russian Federation
Irena A. Ilovayskaya - MD, PhD, Professor.
Moscow
Competing Interests:
none
S. A. Terpigorev
National Medical and Surgical Center named after N.I. Pirogov
Russian Federation
Competing Interests:
Russian Federation
Stanislav A. Terpigorev - MD, PhD, Proffessor.
Moscow
Competing Interests:
none
I. V. Komerdus
Moscow Regional Research and Clinical Institute named after M.F. Vladimirsky
Russian Federation
Competing Interests:
Russian Federation
Irina V. Komerdus - MD, PhD, Associate Professor.
Moscow
Competing Interests:
none
A. Yu. Lugovskaya
Moscow Regional Research and Clinical Institute named after M.F. Vladimirsky
Russian Federation
Competing Interests:
Russian Federation
Anna Y. Lugovskaya – MD.
Moscow
Competing Interests:
none
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Supplementary files
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1. Picture 1. Sagittal (A) and frontal (В) MRI pituitary images of patient M., 33 years old. Supra-endosellar pituitary tumor is visualized. | |
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2. Picture 2. Sarcoidosis of the lungs and intrathoracic lymph nodes in patient M. The lesion of the pulmonary interstitium is manifested by multiple small focal opacities of the lymphomatous distribution, reticular opacities and unexpressed compaction of the peribronchovascular interstitium. | |
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3. Picture 3. Sarcoidosis-related enlargement of mediastinal lymph nodes (paraaortic, upper paratracheal and bifurcation) in patient M. | |
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For citations:
Zakharova P.A., Ilovayskaya I.A., Terpigorev S.A., Komerdus I.V., Lugovskaya A.Yu. Development of sarcoidosis after successful treatment of Cushing’s disease. Problems of Endocrinology. 2023;69(6):47-53. (In Russ.) https://doi.org/10.14341/probl13203
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