Management of primary hyperparathyroidism with rare localization of ectopic adenoma parathyroid gland
https://doi.org/10.14341/probl13425
Abstract
Topical diagnosis can be severely complicated in patients with primary hyperparathyroidism (PHPT) due to the ectopic placement of parathyroid gland (PTG) formations. We report a clinical case of PHPT in an 84-year-old patient caused by ectopic PTG adenoma located behind the right internal jugular vein at the level of the right submandibular gland. The impossibility of surgery for a long time due to the absence of a topical diagnosis has necessitated conservative treatment was required to get the hypercalcemia under control. In view of the concomitant deficiency of vitamin D, an attempt was made to use therapy with saturating doses of cholecalciferol under dynamic monitoring of the indicators of phosphorus-calcium metabolism, which allowed to achieve a significant decrease in PTH levels while maintaining normocalcemia.
About the Authors
E. A. AboishevaRussian Federation
Elizaveta A. Aboisheva, MD
Moscow
E. S. Avsievich
Russian Federation
Ekaterina S. Avsievich
Moscow
M. O. Korchagina
Russian Federation
Maria O. Korchagina
11 Dm. Ulyanova street, 117036 Moscow
M. V. Degtyarev
Russian Federation
Mikhail V. Degtyarev, MD
Moscow
E. E. Bibik
Russian Federation
Ekaterina E. Bibik, MD
Moscow
D. G. Beltsevich
Russian Federation
Dmitriy G. Beltsevich, MD, PhD, Professor
Moscow
E. A. Pigarova
Russian Federation
Ekaterina A. Pigarova
Moscow
M. S. Sheremeta
Russian Federation
Marina S. Sheremeta, PhD
Moscow
References
1. Mokrysheva N.G., Kovaleva E.V., Eremkina A.K. Registries of parathyroid glands diseases in the Russian Federation. Problems of Endocrinology. 2021;67(4):4-7. (In Russ.)] https://doi.org/10.14341/probl12803
2. Mokrysheva N.G., Mirnaya S.S., Dobreva E.A., et al. Primary hyperparathyroidism in Russia according to the registry. Problems of Endocrinology. 2019;65(5):300-310.] https://doi.org/10.14341/probl10126
3. Minisola S, Gianotti L, Bhadada S, Silverberg SJ. Classical complications of primary hyperparathyroidism. Best Pract Res Clin Endocrinol Metab. 2018;32(6):791-803. https://doi.org/10.1016/j.beem.2018.09.001
4. Dandurand K, Ali DS, Khan AA. Primary Hyperparathyroidism: A Narrative Review of Diagnosis and Medical Management. J Clin Med. 2021 Apr 9;10(8):1604. https://doi.org/10.3390/jcm10081604
5. Walker MD, Silverberg SJ. Primary hyperparathyroidism. Nat. Rev. Endocrinol. 2018;14:115-125. https://doi.org/10.1038/nrendo.2017.104
6. Taterra D, Wong LM, Vikse J et al. The Prevalence and Anatomy of Parathyroid Glands: A Meta-Analysis With Implications for Parathyroid Surgery. Langenbecks Arch Surg (2019) 404:63–70. https://doi.org/10.1007/s00423-019-01751-8
7. Hojaij F, Vanderlei F, Plopper C. et al. Parathyroid gland anatomical distribution and relation to anthropometric and demographic parameters: a cadaveric study. Anatomical Science International. 2011; 86(4), 204–212 https://doi.org/10.1007/s12565-011-0111-0;
8. Morris MA, Saboury B, Ahlman M, et al. Parathyroid Imaging: Past, Present, and Future. Front Endocrinol (Lausanne). 2022 Feb 25;12:760419. https://doi.org/10.3389/fendo.2021.760419.
9. Peissig K, Condie BG, Manley NR. Embryology of the Parathyroid Glands. Endocrinol Metab Clin North Am. 2018;47(4):733-742. https://doi.org/10.1016/j.ecl.2018.07.002
10. Khalaf SH, Sarwani AA, George SM, Al Saeed MK. Primary hyperparathyroidism caused by an ectopic parathyroid adenoma in an uncommon location: a case report. J Taibah Univ Med Sci. 2021 Mar 25;16(5):782-787. https://doi.org/10.1016/j.jtumed.2021.02.010
11. Roy M, Mazeh H, Chen H, Sippel RS. Incidence and localization of ectopic parathyroid adenomas in previously unexplored patients. World J Surg. 2013 Jan;37(1):102-6. https://doi.org/10.1007/s00268-012-1773-z.
12. Noussios G, Anagnostis P, Natsis K. Ectopic parathyroid glands and their anatomical, clinical and surgical implications. Exp Clin Endocrinol Diabetes. 2012;120:604–10. https://doi.org/10.1055/s-0032-1327628.;
13. Kuzminski SJ, Sosa JA, Hoang JK. Update in parathyroid imaging. Magn Reson Imaging Clin N Am. 2018;26:151–66. https://doi.org/10.1016/j.mric.2017.08.009.
14. Xin Y, Zhao T, Wei B, Gu H, Jin M, Shen H, Liu X, Wang J, Wang Q. Intrapericardial parathyroid carcinoma: a case report. Endocrine. 2020 Aug;69(2):456-460. https://doi.org/10.1007/s12020-020-02283-8.
15. Hartert M, Tripsky J, Huertgen M. Technique for ectopic intrathymic parathyroid adenoma: the uniportal subxiphoid approach. J Surg Case Rep. 2021 Dec 11;2021(12):rjab520. https://doi.org/10.1093/jscr/rjab520
16. Liu X, Sun L, Shao M, et al. Primary hyperparathyroidism due to ectopic parathyroid adenoma in an adolescent: a case report and review of the literature. Endocrine. 2019 Apr;64(1):38-42. https://doi.org/10.1007/s12020-019-01875-3
17. Cheatem DM, Sturgeon C. Chapter 60 – Technique of parathyroidectomy. In: Orlo HC, Quan-Yang D, Electron K. (eds) Textbook of endocrine surgery, 3rd ed. Jaypee Brothers Medical Publishers, 2016, pp. 747–755. https://doi.org/10.5005/jp/books/12798_61
18. Mokrysheva N.G., Eremkina A.K., Mirnaya S.S., et al. The clinical practice guidelines for primary hyperparathyroidism, short version. Problems of Endocrinology. 2021;67(4):94-124. (In Russ.)] https://doi.org/10.14341/probl12801;
19. Spanu A, Schillaci O, Piras B, Madeddu G. SPECT/CT in hyperparathyroidism. Clin Transl Imaging. 2014;2:537–55. https://doi.org/10.1007/s40336-014-0089-4.;
20. Siraj QH. Radionuclide parathyroid imaging. Cham: Springer; 2020. Chapter 5, Parathyroid Scintigraphy. p. 41–60 https://doi.org/10.1007/978-3-030-17351-7
21. Gouveia S, Rodrigues D, Barros L, et al. Persistent primary hyperparathyroidism: an uncommon location for an ectopic gland--case report and review. Arq Bras Endocrinol Metabol. 2012;56(6):393-403. https://doi.org/10.1590/s0004-27302012000600009
22. Slashchuk K.Y., Degtyarev M.V., Rumyantsev P.O., Troshina E.A., Melnichenko G.A. Imaging methods of the parathyroid glands in primary hyperparathyroidism. Literature review. Endocrine Surgery. 2019;13(4):153-174. (In Russ.)] https://doi.org/10.14341/serg12241
23. Lundstroem AK, Trolle W, Soerensen CH, Myschetzky PS. Preoperative localization of hyperfunctioning parathyroid glands with 4D-CT. Eur Arch Otorhinolaryngol. 2016;273(5):1253-1259. https://doi.org/10.1007/s00405-015-3509-9;
24. Hinson AM, Lee DR, Hobbs BA, et al. Preoperative 4D CT Localization of Nonlocalizing Parathyroid Adenomas by Ultrasound and SPECT-CT. Otolaryngol Head Neck Surg. 2015;153(5):775-778. https://doi.org/10.1177/0194599815599372
25. Treglia G, Piccardo A, Imperiale A, et al. Diagnostic performance of choline PET for detection of hyperfunctioning parathyroid glands in hyperparathyroidism: a systematic review and meta-analysis. Eur J Nucl Med Mol Imaging. 2019;46(3):751-765. https://doi.org/10.1007/s00259-018-4123-z
26. Beheshti M, Hehenwarter L, Paymani Z, et al. 18F-Fluorocholine PET/CT in the assessment of primary hyperparathyroidism compared with 99mTc-MIBI or 99mTc-tetrofosmin SPECT/CT: a prospective dual-centre study in 100 patients. Eur J Nucl Med Mol Imaging. 2018;45(10):1762-1771. https://doi.org/10.1007/s00259-018-3980-9
27. Hayakawa N, Nakamoto Y, Kurihara K, et al. A comparison between 11C-methionine PET/CT and MIBI SPECT/CT for localization of parathyroid adenomas/hyperplasia. Nucl Med Commun. 2015;36(1):53-59. https://doi.org/10.1097/MNM.0000000000000216
28. Mathey C, Keyzer C, Blocklet D, et al. 18F-Fluorocholine PET/CT Is More Sensitive Than 11C-Methionine PET/CT for the Localization of Hyperfunctioning Parathyroid Tissue in Primary Hyperparathyroidism. J Nucl Med. 2022;63(5):785-791. https://doi.org/10.2967/jnumed.121.262395
29. Scattergood S, Marsden M, Kyrimi E, et al. Combined ultrasound and Sestamibi scintigraphy provides accurate preoperative localisation for patients with primary hyperparathyroidism. Ann R Coll Surg Engl. 2019;101(2):97-102. https://doi.org/10.1308/rcsann.2018.0158
30. Boudou P, Ibrahim F, Cormier C, et al. A very high incidence of low 25 hydroxy-vitamin D serum concentration in a French population of patients with primary hyperparathyroidism. J Endocrinol Invest. 2006 Jun;29(6):511-5. https://doi.org/10.1007/BF03344140. PMID: 16840828.]
31. Walker MD, Bilezikian JP. Vitamin D and primary hyperparathyroidism: more insights into a complex relationship. Endocrine. 2017 Jan;55(1):3-5. https://doi.org/10.1007/s12020-016-1169-1
32. Dandurand K, Ali DS, Khan AA. Primary Hyperparathyroidism: A Narrative Review of Diagnosis and Medical Management. J Clin Med. 2021 Apr 9;10(8):1604. https://doi.org/10.3390/jcm10081604.
33. Song A, Zhao H, Yang Y, et al. Safety and efficacy of common vitamin D supplementation in primary hyperparathyroidism and coexistent vitamin D deficiency and insufficiency: a systematic review and meta-analysis. J Endocrinol Invest. 2021 Aug;44(8):1667-1677. https://doi.org/10.1007/s40618-020-01473-5.
34. Shah VN, Shah CS, Bhadada SK, Rao DS. Effect of 25 (OH) D replacements in patients with primary hyperparathyroidism (PHPT) and coexistent vitamin D deficiency on serum 25(OH) D, calcium and PTH levels: a meta-analysis and review of literature. Clin Endocrinol (Oxf). 2014 Jun;80(6):797-803. https://doi.org/10.1111/cen.12398
35. Rolighed L, Rejnmark L, Sikjaer T, et al. Vitamin D treatment in primary hyperparathyroidism: a randomized placebo controlled trial. J Clin Endocrinol Metab. 2014 Mar;99(3):1072-80. https://doi.org/10.1210/jc.2013-3978
36. Tucci JR. Vitamin D therapy in patients with primary hyperparathyroidism and hypovitaminosis D. Eur J Endocrinol. 2009 Jul;161(1):189-93. https://doi.org/10.1530/EJE-08-0901
Supplementary files
|
1. Figure 1. SPECT/CT with 99mTc-technetrile from December 2021 | |
Subject | ||
Type | рисунок | |
View
(612KB)
|
Indexing metadata ▾ |
|
2. Figure 2. Contrast-enhanced MSCT of the neck from December 2021 | |
Subject | ||
Type | Other | |
View
(1MB)
|
Indexing metadata ▾ |
Review
For citations:
Aboisheva E.A., Avsievich E.S., Korchagina M.O., Degtyarev M.V., Bibik E.E., Beltsevich D.G., Pigarova E.A., Sheremeta M.S. Management of primary hyperparathyroidism with rare localization of ectopic adenoma parathyroid gland. Problems of Endocrinology. 2025;71(1):20-26. (In Russ.) https://doi.org/10.14341/probl13425

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND 4.0).