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The role of an interdisciplinary approach to the treatment of patients with reduced ovarian reserve, premature ovarian insufficiency and mood disorders

https://doi.org/10.14341/probl13576

Abstract

Diminished ovarian reserve and premature ovarian insufficiency (POI) are the pathologies associated with poor reproductive prognosis, decreased estrogen production, and the development of multiple complications of hypoestrogenism. Currently, in the absence of a response to superovulation stimulation, the most likely way for patients with these conditions to achieve pregnancy is through the use of a donor oocyte. In addition, the condition of the patient presented in the second clinical description is aggravated the pathology of carbohydrate metabolism. However, the management of these women often overlooks their mental exhausting which exacerbates the underlying condition. In this publication, we present descriptions of patients with diminished ovarian reserve and POI with concomitant mood disorders who wish to become pregnant. Both patients were treated under dynamic monitoring by a psychotherapist with positive results. Moreover, spontaneous pregnancy occurred in both women described in this article. These clinical cases highlight the importance of a multidisciplinary approach in managing women with ovarian insufficiency to enhance treatment effectiveness and restore reproductive function.

About the Authors

Y. S. Absatarova
I.I. Dedov Endocrinology Research Centre
Russian Federation

Yulia S. Absatarova, MD, PhD

Moscow



Y. S. Evseeva
I.I. Dedov Endocrinology Research Centre
Russian Federation

Yulia S. Evseeva, MD, resident

Moscow, st. Dmitry Ulyanov, 11, 117292



T. A. Zelenkova-Zakharchuk
I.I. Dedov Endocrinology Research Centre
Russian Federation

Tatyana A. Zelenkova-Zakharchuk, MD, PhD

Moscow



E. N. Andreeva
I.I. Dedov Endocrinology Research Centre; Russian university of medicine
Russian Federation

Elena N. Andreeva, MD, PhD, professor

Moscow



E. V. Sheremetyeva
I.I. Dedov Endocrinology Research Centre
Russian Federation

Ekaterina V. Sheremetyeva, MD, PhD

Moscow



O. R. Grigoryan
I.I. Dedov Endocrinology Research Centre
Russian Federation

Olga R. Grigoryan, MD, PhD, professor

Moscow



References

1. Panay N, Anderson RA, Bennie A, et al. Evidence-based guideline: premature ovarian insufficiency. Human reproduction open. 2024;2024(4):hoae065. doi: https://doi.org/10.1093/hropen/hoae065

2. Li M, Zhu Y, Wei J, et al. The global prevalence of premature ovarian insufficiency: a systematic review and meta-analysis. Climacteric. 2023;26(2):95-102. doi: https://doi.org/10.1080/13697137.2022.2153033

3. Zhenskoe besplodie. Klinicheskie rekomendacii. M.: Ministerstvo zdravoohraneniya Rossijskoj federacii. 2024. (In Russ.)

4. Мarchenko LA, Mashaeva RI. Clinical and laboratory criteria for occult form of premature ovarian failure. Gynecology. 2018;20(6):73–76. (In Russ.) doi: https://doi.org/10.26442/20795696.2018.6.180069

5. Li XT, Li PY, Liu Y, et al. Health-related quality-of-life among patients with premature ovarian insufficiency: A systematic review and meta-analysis. Quality of life research: an international journal of quality of life aspects of treatment, care and rehabilitation. 2020;29:19–36. doi: https://doi.org/10.1007/s11136-019-02326-2

6. Menezes C, Pravata GR, Yela DA, Benetti-Pinto CL. Women with premature ovarian failure using hormone therapy do not experience increased levels of depression, anxiety and stress compared to controls. Journal of affective disorders. 2020;273:562–566. doi: https://doi.org/10.1016/j.jad.2020.05.105

7. Song D, Li X, Yang M, et al. Fertility quality of life (FertiQoL) among Chinese women undergoing frozen embryo transfer. BMC women’s health. 2021;21(1):177. doi: https://doi.org/10.1186/s12905-021-01325-1

8. Andreeva EN, Absatarova YuS, Akhmatova RR, et al. Primary ovarian insufficiency: from basis of pathogenesis to treatment perspectives. Vopr. ginekol. akus. perinatol. (Gynecology, Obstetrics and Perinatology). 2021;20(5):100–107. (In Russ.) doi: https://doi.org/10.20953/1726-1678-2021-5-100-107

9. Gava G, Orsili I, Alvisi S, et al. Cognition, mood and sleep in menopausal transition: the role of menopause hormone therapy. Medicina (Kaunas). 2019;55(10):668. doi: https://doi.org/10.3390/medicina55100668

10. Miller AH. Depression and immunity: a role for T cells? Brain, behavior, and immunity. 2010;24(1):1-8. doi: https://doi.org/10.1016/j.bbi.2009.09.009

11. Zefferino R, Di Gioia S, Conese M. Molecular links between endocrine, nervous and immune system during chronic stress. Brain and behavior. 2021;11(2):e01960. doi: https://doi.org/10.1002/brb3.1960

12. Golezar S, Keshavarz Z, Ramezani Tehrani F, Ebadi A. An exploration of factors affecting the quality of life of women with primary ovarian insufficiency: a qualitative study. BMC women’s health. 2020;20:163. doi: https://doi.org/10.1186/s12905-020-01029-y

13. Absatarova YS, Andreeva EN, Evseeva YS, et al. Endocrine and psychosomatic disorders in patients with amenorrhea. Problems of Endocrinology. 2023;69(6):121-131 doi: https://doi.org/10.14341/probl13366

14. Goldstein JM, Jerram M, Poldrack R, et al. Hormonal cycle modulates arousal circuitry in women using functional magnetic resonance imaging. The Journal of neuroscience: the official journal of the Society for Neuroscience. 2005;25(40):9309 9316. doi: https://doi.org/10.1523/JNEUROSCI.2239-05.2005

15. Protopopescu X, Pan H, Altemus M, et al. Orbitofrontal cortex activity related to emotional processing changes across the menstrual cycle. Proceedings of the National Academy of Sciences of the United States of America. 2005;102(44):16060-16065. doi: https://doi.org/10.1073/pnas.0502818102

16. Tian Y, Zhang X, Xin Z, et al. Premature Ovarian Insufficiency Is Associated with Increased Risk of Depression, Anxiety, and Poor Life Quality: A Systematic Review and Meta-analysis. Alpha Psychiatry. 2024;25(2):132-141. doi: https://doi.org/10.5152/alphapsychiatry.2024.231501

17. Suryawanshi O 4th, Pajai S. A Comprehensive Review on Postpartum Depression. Cureus. 2022;14(12):e32745. doi: https://doi.org/10.7759/cureus.32745

18. Liu X, Wang S, Wang G. Prevalence and Risk Factors of Postpartum Depression in Women: A Systematic Review and Meta-analysis. Journal of clinical nursing. 2022;31(19-20):2665-2677. doi: https://doi.org/10.1111/jocn.16121


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For citations:


Absatarova Y.S., Evseeva Y.S., Zelenkova-Zakharchuk T.A., Andreeva E.N., Sheremetyeva E.V., Grigoryan O.R. The role of an interdisciplinary approach to the treatment of patients with reduced ovarian reserve, premature ovarian insufficiency and mood disorders. Problems of Endocrinology. 2025;71(3):68-74. (In Russ.) https://doi.org/10.14341/probl13576

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ISSN 0375-9660 (Print)
ISSN 2308-1430 (Online)