Dynamics of glycemia following subcutaneous administration of Rinsulins NPH and P in comparison with insulins Protaphane and Actrapid at the onset of insulinotherapy in the patients with type 2 diabetes mellitus

Abstract

The introduction of novel insulin analogs into medical practice requires clinical data confirming their comparability with the currently used preparations. The objective of present work was to compare the hypoglycemic action of a single injection of Rinsulins NPH and P (Natsional'nye tekhnologii, Russia) on the one hand and insulins Protaphane and Actrapid (Novo Nordisk, Denmark) on the other hand in 18 insulin-naïve patients with type 2 diabetes mellitus treated in the hospital environment. The tested analogs were randomly administered to the patients within 4 days after hospitalization. Blood glucose levels were measured ten times each day. No significant difference in the dynamics of glycemia between the patients treated with either group of preparations was documented.