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Воспаление жировой ткани (часть 4). Ожирение - новое инфекционное заболевание? (обзор литературы)

https://doi.org/10.14341/probl201157563-71

Аннотация

В обзоре описана роль аденовируса 36, Сhlamydia pneumoniae, Helicobacter pylori, Trypanosoma cruzi в развитии ожирения. Заражение указанными микроорганизмами ведет к развитию ожирения у животных; у людей с ожирением чаще обнаруживаются антитела к ним. В качестве причины развития ожирения обсуждается активация компонентами микроорганизмов рецепторов врожденной иммунной системы - TLR2 и TLR4, локализующихся в жировой ткани. Насыщенные жирные кислоты, как и липополисахариды, входящие в состав микроорганизмов, являются лигандами TLR2 и TLR4. За счет активации TLR2 и TLR4 они способствуют развитию воспаления жировой ткани и инсулинорезистентности, тем самым, развитию ожирения. Активация TLR2 и TLR4 при инфекции, угнетая чувствительность к инсулину жировых, печеночных и мышечных клеток, ведет к повышению уровня в крови глюкозы и жирных кислот, обеспечивая иммунные процессы энергетическими субстратами. То обстоятельство, что насыщенные жирные кислоты и компоненты структур микроорганизмов являются лигандами рецепторов врожденной иммунной системы и вызывают идентичные реакции, свидетельствует о возможности кумулятивного действия диетических излишеств и некоторых видов микроорганизмов.

Об авторе

V Shvarts



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Для цитирования:


. Воспаление жировой ткани (часть 4). Ожирение - новое инфекционное заболевание? (обзор литературы). Проблемы Эндокринологии. 2011;57(5):63-71. https://doi.org/10.14341/probl201157563-71

For citation:


Shvarts V.I. Inflammation of the adipose tissue (Part 4). Obesity: a new infectious disease? (a literature review). Problems of Endocrinology. 2011;57(5):63-71. (In Russ.) https://doi.org/10.14341/probl201157563-71

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