Disturbed balance of steroid hormones in men under 40 years of age presenting with obesity and metabolic syndrome

G V Katsiia; N P Goncharov; N A Chagina

doi:10.14341/probl20115747-12

Disturbed balance of steroid hormones in men under 40 years of age presenting with obesity and metabolic syndrome

G V Katsiia, N P Goncharov, N A Chagina

https://doi.org/10.14341/probl20115747-12

Abstract

We have studied steroid hormone profiles in young men with normal body mass index suffering obesity and metabolic syndrome. They showed a consistent tendency toward a shift in blood aldosterone level to the upper normal level and beyond. It was higher in patients with metabolic syndrome than with obesity. The testosterone levels displayed the downward trend from normal through obesity to metabolic syndrome values. The main predictors of testosterone dynamics in the course of development of obesity and metabolic syndrome were insulin concentration and BMI. Dynamics of dehydroepiandrosterone levels followed that of testosterone. It significantly decreased in men with metabolic syndrome compared with health subjects. Young men presenting with obesity and metabolic syndrome did not experience changes in morning and evening cortisol levels in peripheral blood. The study revealed the relationship between aldosterone levels and the development of metabolic syndrome mediated through the body mass index and the direct relationship between metabolic syndrome and testosterone dynamics.

Keywords

obesity, metabolic syndrome, aldosterone, testosterone, dehydroepiandrosterone sukfate, cortisol

About the Authors

G V Katsiia

N P Goncharov

N A Chagina

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Review

For citations:

Katsiia G.V., Goncharov N.P., Chagina N.A. Disturbed balance of steroid hormones in men under 40 years of age presenting with obesity and metabolic syndrome. Problems of Endocrinology. 2011;57(4):7-12. https://doi.org/10.14341/probl20115747-12

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND 4.0).

ISSN 0375-9660 (Print)
ISSN 2308-1430 (Online)

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