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The antioxidative activity of oral hypoglycemic agents

https://doi.org/10.14341/probl201157421-24

Abstract

Oral hypoglycemic agents, such as glibenclamide, gliclazide, metformin, rosiglitazone maleate, and diabenol, are known to exert in vitro a mild direct antioxidatove action. Rosiglitazone maleate showed moderate activity only on the hemiluminescence model with generation of active oxygen species while diabenol behaves as a scavenger of superoxide anion and hydroxyl radical in model hemiluminescence systems. Gliclazide exhibited dose-dependent activity only with respect to stable diphenyl-1-picrylhydrazyl (DPPG) radicals. Metformin and glibenclamide were inactive under in vitro conditions. It is hypothesized that the antioxidative action of hypoglycemic agents used for long-term pharmacotherapy should be attributed to their direct effect on the activity of enzymes of the antioxdative system.

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For citations:


Spasov A.A., Kosolapov V.A., Chepliaeva N.I. The antioxidative activity of oral hypoglycemic agents. Problems of Endocrinology. 2011;57(4):21-24. https://doi.org/10.14341/probl201157421-24

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