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Акромегалия: современные достижения в диагностике и лечении

https://doi.org/10.14341/probl201157146-59

Аннотация

Акромегалия -– тяжелое нейроэндокринное заболевание, сопровождающееся развитием многообразных осложнений, приводящих к ранней инвалидизации и сокращению продолжительности жизни. Только своевременное выявление заболевания и применение современных методов лечения позволяют добиться надежного результата и оптимизировать качество жизни больных. В настоящее время консенсусом 2010 г. определены оптимальные лабораторные тесты как с целью диагностики данного заболевания, так и мониторинга после проведения различных видов терапии. Это оральный глюкозотолерантный тест (ОГТТ) с определением уровня СТГ, а также исследование уровня общего ИРФ1. Принято решение считать, что заболевание контролируемо, если базальный или случайный уровень СТГ составляет менее 1 нг/мл, минимальный уровень СТГ в ходе ОГТТ - менее 0,4 нг/мл и показатель ИРФ1 соответствует норме. Оптимальным методом визуализации аденомы гипофиза признана МРТ с контрастным усилением. Последние десятилетия разработаны эффективные методы лечения акромегалии, включая транссфеноидальную аденомэктомию с применением высокотехнологичного нейрохирургического оснащения, узкофокусированные методы лучевой терапии, а также современные средства медикаментозной терапии, включая длительно действующие мультилигандные аналоги соматостатина, антагонисты рецепторов гормона роста.

Об авторе

N Molitvoslovova



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Для цитирования:


. Акромегалия: современные достижения в диагностике и лечении. Проблемы Эндокринологии. 2011;57(1):46-59. https://doi.org/10.14341/probl201157146-59

For citation:


Molitvoslovova N.N. Acromegaly: recent progress in diagnostics and treatment. Problems of Endocrinology. 2011;57(1):46-59. (In Russ.) https://doi.org/10.14341/probl201157146-59

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