Роль специфических шаперонов в патогенезе ожирения и ассоциированных с ним заболеваний

Ожирение, сахарный диабет 2-го типа и атеросклероз связаны с развитием "метаболического" воспаления. В адипоцитах и макрофагах провоспалительные механизмы могут быть инициированы как внеклеточными медиаторами (цитокины, насыщенные жирные кислоты), так и внутриклеточными компонентами (стресс эндоплазматического ретикулума, избыточная продукция свободных радикалов). Важную роль в развитии "метаболического" воспаления играют внутриклеточные белки - переносчики жирных кислот ("fatty acid-binding proteins").

ожирение, "метаболическое" воспаление, шапероны

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