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Ингибиторы дипептидилпептидазы-4: сравнительный анализ представителей группы

https://doi.org/10.14341/probl201258161-66

Аннотация

Ингибиторы дипептидилпептидазы-4 (ДПП-4) - новый класс сахарснижающих препаратов, разработанных с учетом появившихся в XXI веке знаний о физиологии инкретинов. В настоящий момент появилось пять представителей данного класса, три из которых доступны на российском рынке. Ингибиторы ДПП-4 оказывают сахарснижающее действие за счет снижения тощаковой и постпрандиальной гипергликемии, не вызывают увеличения массы тела и имеют благоприятный профиль побочных эффектов. Тем не менее ингибиторы ДПП-4 отличаются по своей фармакодинамике и фармакокинетике, что обусловливает различия в длительности их действия, лекарственных взаимодействиях, возможности применения у отдельных категорий пациентов. В статье представлена сравнительная характеристика трех ингибиторов ДПП-4: вилдаглиптина, ситаглиптина и саксаглиптина.

Об авторах

E Shestakova



G Galstian



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Для цитирования:


., . Ингибиторы дипептидилпептидазы-4: сравнительный анализ представителей группы. Проблемы Эндокринологии. 2012;58(1):61-66. https://doi.org/10.14341/probl201258161-66

For citation:


Shestakova E.A., Galstian G.R. Dipeptidyl peptidase-4 inhibitors: Comparative analysis of members of the group. Problems of Endocrinology. 2012;58(1):61-66. (In Russ.) https://doi.org/10.14341/probl201258161-66

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