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Проблемы Эндокринологии

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Нарушения в системе гемостаза при эндогенном гиперкортицизме и метаболическом синдроме

https://doi.org/10.14341/probl201056434-38

Аннотация

Длительная гиперкортизолемия сопровождается множественными дефектами регуляции различных обменов веществ. Вместе с метаболическими эффектами глюкокортикоиды оказывают действие непосредственно на сосудистую стенку, влияя на ее ремоделирование и ангиогенез. Синдром эндогенного гиперкортицизма характеризуется достаточно разно­образными нарушениями системы гемостаза с тенденцией к гиперкоагуляции. Изменения метаболических и гемостатических показателей в активной стадии заболевания длительное время не нормализуются в стадии ремиссии, в связи с чем сохраняется риск развития атеросклероза, атеротромбоза и тромбоэмболических осложнений, что обусловливает необходимость последующей медикаментозной их коррекции. По данным зарубежной литературы, тромбоэмболические осложнения являются основной причиной смертности у данных больных и встречаются в 4 раза чаще, чем в популяции.

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Для цитирования:


., ., ., ., . Нарушения в системе гемостаза при эндогенном гиперкортицизме и метаболическом синдроме. Проблемы Эндокринологии. 2010;56(4):34-38. https://doi.org/10.14341/probl201056434-38

For citation:


Khodakova I.V., Arapova S.D., Sukhanova G.A., Chirkova L.D., Rozhinskaia L.I. Disturbances in the hemostatic system of patients with endogenous hypercorticism and metabolic syndrome. Problems of Endocrinology. 2010;56(4):34-38. (In Russ.) https://doi.org/10.14341/probl201056434-38

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