Expression of somatostatin and dopamine receptors in ACTH-producing tumours

I I Dedov; E I Marova; A Iu Abrosimov; A M Lapshina; A Iu Grigor'ev; Iu A  Ablitsov; N S Kuznetsov; N P Goncharov; S D Arapova; L Ia Rozhinskaia

doi:10.14341/probl201056114-18

Expression of somatostatin and dopamine receptors in ACTH-producing tumours

I I Dedov, E I Marova, A Iu Abrosimov, A M Lapshina, A Iu Grigor'ev, Iu A Ablitsov, N S Kuznetsov, N P Goncharov, S D Arapova, L Ia Rozhinskaia

https://doi.org/10.14341/probl201056114-18

Abstract

This study was designed to compare immunoexpression of somatostatin receptors (SR)1-5 and dopamine receptors 2 (DR2) in pituitary and non-pituitary ectopic ACTH-producing tumours. A total of 35 patients were enrolled in the study including 21 with Cushing's disease (CD) and 14 with ACTH-ectopic syndrome (ACTH-ES) associated with carcinoid tumours of lungs (n=11), kidney (n=1), thymus (n=1) and with small-cell lung carcinoma (n=1). All patients with corticotropinomas exhibited expression of SR 1-5 dominated by SR-1 (57%). 81% of these tumours expressed two and more SR subtypes. DR2 expression was documented in 52% of the tumours and co-expression of DR2 with different SR subtypes in 29%. Neoplasms associated with ACTH-ES expressed SR with the predominance of SR-3 (72%). Half of these tumours co-expressed two and more SR subtypes. Expression of DR2 was demonstrated in 50% of the neoplasms associated with ACTH-ES; 38% of them co-expressed SR and DF2.

Keywords

ACTH-producing tumours, immunoexpression of somatostatin and dopamine receptors

About the Authors

I I Dedov

E I Marova

A Iu Abrosimov

A M Lapshina

A Iu Grigor'ev

Iu A Ablitsov

N S Kuznetsov

N P Goncharov

S D Arapova

L Ia Rozhinskaia

References

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Review

For citations:

Dedov I.I., Marova E.I., Abrosimov A.I., Lapshina A.M., Grigor'ev A.I., Ablitsov I.A., Kuznetsov N.S., Goncharov N.P., Arapova S.D., Rozhinskaia L.I. Expression of somatostatin and dopamine receptors in ACTH-producing tumours. Problems of Endocrinology. 2010;56(1):14-18. https://doi.org/10.14341/probl201056114-18

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND 4.0).

ISSN 0375-9660 (Print)
ISSN 2308-1430 (Online)

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Problems of Endocrinology

Expression of somatostatin and dopamine receptors in ACTH-producing tumours

Abstract

Keywords

About the Authors

References

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