The state of the guanylate cyclase mechanism of vasodilatation before and after thyroidectomy in the patients presenting with toxic goiter
https://doi.org/10.14341/probl201460315-22
Abstract
The state of the guanylate cyclase activity of myocytes was evaluated from the increment in the diameter of the brachial artery in response to the exogenous administration of nitroglycerin (#D^NO) in 64 samples obtained from 44 patients. A total of 23 studies were carried out during thyrotoxicosis decompensation, 28 ones in the phase of medicamental thyrotoxicosis, and 13 within 5-6 days after thyroidectomy. The guanylate cyclase activity of myocytes was found to correlate with the production of vascular endothelium factors. Thyroidectomy in the patients with toxic goiter and reduced guanylate cyclase activity of myocytes was associated with the statistically significant increase of endothelium-independent vasodilatation.
About the Authors
E A Ilyicheva
Scientific center of reconstructive and restorative surgery of the Siberian branch of the Russian Academy of Medical Science, Irkutsk
Russian Federation
Russian Federation
I F Tarnueva
Scientific center of reconstructive and restorative surgery of the Siberian branch of the Russian Academy of Medical Science, Irkutsk
Russian Federation
Russian Federation
Yu I Pivovarov
Scientific center of reconstructive and restorative surgery of the Siberian branch of the Russian Academy of Medical Science, Irkutsk
Russian Federation
Russian Federation
L B Koryakina
Scientific center of reconstructive and restorative surgery of the Siberian branch of the Russian Academy of Medical Science, Irkutsk
Russian Federation
Russian Federation
E A Chizhova
Scientific center of reconstructive and restorative surgery of the Siberian branch of the Russian Academy of Medical Science, Irkutsk
Russian Federation
Russian Federation
References
1. Зеленева Н.В. Ультразвуковая диагностика нарушений функции эндотелия и особенности изменений сосудистого русла у больных ревматоидным артритом и системной красной волчанкой. // Вестник Российского научного центра рентгенорадиологии Минздрава России. 2010;1(10):22. [Zeleneva NV. Sonographic diagnostics of endothelial function impairment and features of vascular changes in patients with rheumatoid arthritis and systemic lupus erythematosus. Vestnik (Herald) of the Russian Scientific Center of Roentgen Radiology. 2010;1(10):22.]
2. Maruhashi T, Soga J, Fujimura N, Idei N, Mikami S, Iwamoto Y, et al. Nitroglycerine-Induced Vasodilation for Assessment of Vascular Function: A Comparison With Flow-Mediated Vasodilation. Arteriosclerosis, Thrombosis, and Vascular Biology. 2013;33(6):1401-1408. doi: 10.1161/atvbaha.112.300934
3. Deniz F, Ermiş N, Kepez A, Türk B, Akkoyunlu M, Kara B, et al. Evaluation of vascular reactivity of young male hypogonadotrophic hypogonadism patients. The International Journal of Cardiovascular Imaging. 2009;26(1):35-40. doi: 10.1007/s10554-009-9505-7
4. Villa P, Costantini B, Suriano R, Perri C, Macrì F, Ricciardi L, et al. The Differential Effect of the Phytoestrogen Genistein on Cardiovascular Risk Factors in Postmenopausal Women: Relationship with the Metabolic Status. The Journal of Clinical Endocrinology & Metabolism. 2009;94(2):552-558. doi: 10.1210/jc.2008-0735
5. McAllister RM. Thyroid status and nitric oxide in rat arterial vessels. Journal of Endocrinology. 2005;185(1):111-119. doi: 10.1677/joe.1.06022
6. Lockette W, Otsuka Y, Hirt E. The endothelium and cyclic guanosine monophosphate in hyperthyroid-induced hypertension. Agents Actions Suppl. 1987;(22):125-132.
7. Ortega J, Vila JM, Mauricio MD, Segarra G, Medina P, Martinez-Leon JB, et al. Nitric oxide mediates abnormal responsiveness of thyroid arteries in methimazole-treated patients. European Journal of Endocrinology. 2005;152(4):551-556. doi: 10.1530/eje.1.01889
8. Motohashi S, Kasai K, Banba N, Hattori Y, Shimoda S-I. Nitric oxide inhibits cell growth in cultured human thyrocytes. Life Sciences. 1996;59(14):PL227-PL234. doi: 10.1016/0024-3205(96)00437-7
9. Iwatani Y, Numa H, Atagi S, Takayama F, Mio M, Kawasaki H. Mechanisms Underlying Enhanced Vasodilator Responses to Various Vasodilator Agents following Endothelium Removal in Rat Mesenteric Resistance Arteries. Yakugaku Zasshi Journal of the Pharmaceutical Society of Japan. 2007;127(4):729-733. doi: 10.1248/yakushi.127.729
10. Lind L, Syvänen AC, Axelsson T, Lundmark P, Hägg S, Larsson A. Variation in genes in the endothelin pathway and endothelium-dependent and endothelium-independent vasodilation in an elderly population. Acta Physiologica. 2013;208(1):88-94. doi: 10.1111/apha.12068
11. Chu CH, Lee JK, Keng HM, Chuang MJ, Lu CC, Wang MC, et al. Hyperthyroidism is associated with higher plasma endothelin-1 concentrations. Exp Biol Med (Maywood). 2006;231(6):1040-1043.
12. Tilly N, Schneider JG, Leidig-Bruckner G, Sommer U, Kasperk C. Endothelin-1 Levels in Patients with Disorders of the Thyroid Gland. Experimental and Clinical Endocrinology & Diabetes. 2003;111(2):80-84. doi: 10.1055/s-2003-39234
13. Gasińska T, Dec R, Słomian U, Starzewski J. Endothelin ET-1 in patients with non-toxic nodular goiter. Pol Arch Med Wewn. 2004;112(4):1167-1171.
14. Donnini D, Ambesi-Impiombato FS, Curcio F. Thyrotropin Stimulates Production of Procoagulant and Vasodilatative Factors in Human Aortic Endothelial Cells. Thyroid. 2003;13(6):517-521. doi: 10.1089/105072503322238764
15. Lam HC, Wang JP, Lee JK, Ho LT, Han TM, Lu CC, et al. Tissue Contents of Endothelin Vary According to Thyroid Hormone Status in Rat. Journal of Cardiovascular Pharmacology. 1993;22(Supplement 8):S299-S302. doi: 10.1097/00005344-199322008-00078
16. Papaioannou GI, Lagasse M, Mather JF, Thompson PD. Treating hypothyroidism improves endothelial function. Metabolism. 2004;53(3):278-279. doi: 10.1016/j.metabol.2003.10.003
17. Duman D, Sahin S, Esertas K, Demirtunc R. Simvastatın improves endothelial function in patents with subclinical hypothyroidism. Heart and Vessels. 2007;22(2):88-93. doi: 10.1007/s00380-006-0950-0
18. Dardano A, Ghiadoni L, Plantinga Y, Caraccio N, Bemi A, Duranti E, et al. Recombinant Human Thyrotropin Reduces Endothelium-Dependent Vasodilation in Patients Monitored for Differentiated Thyroid Carcinoma. The Journal of Clinical Endocrinology & Metabolism. 2006;91(10):4175-4178. doi: 10.1210/jc.2006-0440
19. Napoli R, Biondi B, Guardasole V, D'Anna C, De Sena A, Pirozzi C, et al. Enhancement of Vascular Endothelial Function by Recombinant Human Thyrotropin. The Journal of Clinical Endocrinology & Metabolism. 2008;93(5):1959-1963. doi: 10.1210/jc.2007-2797
20. Латыпова В.Н., Дамдиндордж Д., Идрисова Е.М., Саприна Т.В., Ворожцова И.Н. Анализ эндотелиальной дисфункции пациентов с аутоиммунным тиреоидитом в зависимости от функционального состояния щитовидной железы. // Сибирский медицинский журнал (г. Томск). 2011;26(4-2):172-176. [Latypova VN, Damdindordzh D, Idrisova EM, Saprina TV, Vorozhtsova IN. Analysis of endothelial dysfunction in patients with autoimmmune thyroiditis depending on the functional state of the thyroid gland. Siberian medical journal. 2011;26(4-2):172-176.]
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For citations:
Ilyicheva E.A., Tarnueva I.F., Pivovarov Yu.I., Koryakina L.B., Chizhova E.A. The state of the guanylate cyclase mechanism of vasodilatation before and after thyroidectomy in the patients presenting with toxic goiter. Problems of Endocrinology. 2014;60(3):15-22. (In Russ.) https://doi.org/10.14341/probl201460315-22
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