The levels of adipocyte protein, a transporter of fatty acids, and adiponectin in the adolescents presenting with obesity and their relationship with the distribution of the adipose tissue
https://doi.org/10.14341/probl201460213-19
Abstract
This study included 130 patients at the age of 14-17 years presenting with constitutional exogenous obesity (CEO) and 24 children without obesity (controls). The levels of adipocyte protein, a transporter of fatty acids (FABP4), in the sera of the adolescents with CEO were significantly higher than in the absence of obesity. They did not depend on the stage of puberty and differed in the children of different sex. The serum adiponectin level in the boys showed negative correlation with the amount of visceral adipose tissue and decreased progressively with the increase in the degree of obesity. The rise in the serum FABP4 level in the girls was associated with the increase in the amount of subcutaneous adipose tissue and positively correlated with the severity of obesity. Visceral obesity in the adolescents was accompanied by a variety of metabolic disorders while changes in the waist circumference did not reflect dynamics in the amount of visceral adipose tissue.
About the Authors
P L Okorokov
Endocrinology Research Centre, Moscow
O V Vasyukova
Endocrinology Research Centre, Moscow
A V Vorontsov
Endocrinology Research Centre, Moscow
A V Ilyin
Endocrinology Research Centre, Moscow
V P Vladimirova
Endocrinology Research Centre, Moscow
E V Averkieva
Endocrinology Research Centre, Moscow
References
1. Whitaker RC, Wright JA, Pepe MS, Seidel KD, Dietz WH. Predict- ing obesity in young adulthood from childhood and parental obesity. New Engl J Med 1997; 337(13): 869-873.
2. Frystyk J, Berne C, Berglund L, Jensevik K, Flyvbjerg A, Zethelius B. Serum adiponectin is a predictor of coronary heart disease: a population-based 10-year follow-up study in elderly men. J Clin Endocrinol Metabol 2007; 92(2): 571-576.
3. Li S, Shin HJ, Ding EL, van Dam RM. Adiponectin levels and risk of type 2 diabetes. A systematic review and meta-analysis. JAMA 2009; 302: 2: 179-188. doi: 10.1001/jama. 2009.976.
4. Васюкова О.В., Окороков П.Л. Роль специфических шаперонов в патогенезе ожирения и ассоциированных с ним заболеваний. // Проблемы эндокринологии. - 2012. - Т.58. - №4 - С.48-53.
5. Tso AW, Xu A, Sham PC, Wat NM, Wang Y, Fong CH, et al. Serum adipocyte fatty acid binding protein as a new biomarker predicting the development of type 2 diabetes: a 10-year prospective study in a Chinese cohort. Diabet Care 2007; 30(10): 2667-2672.
6. Xu A, Tso AW, Cheung BM, Wang Y, Wat NM, Fong CH, et al. Circulating Adipocyte Fatty Acid Binding Protein levels predict the development of the metabolic syndrome: a 5-year prospective study. Circulation 2007; 115(12): 1537-1543.
7. von Eynatten M, Breitling LP, Roos M, Baumann M, Rothenbacher D, Brenner H. Circulating adipocyte fatty acid-binding protein levels and cardiovascular morbidity and mortality in patients with coronary heart disease. Arterioscler Throm Vasc Biol 2012; 32(9):2327-2335. doi: 10.1161/ATVBAHA.112.248609.
8. Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, et al. Cloning of adiponectin receptor receptors that mediate antidiabetic metabolic effects. Nature 2003; 423(6941): 762-769.
9. Васюкова О.В. Инсулин, лептин, липиды и периферические ростовые факторы при ожирении у детей: Автореф. дисс. ... канд. мед. наук. - М., 2006.
10. Reinehr T, Stoffel-Wagner B, Roth CL. Adipocyte fatty acid-binding protein in obese children before and after weight loss. Metabolism 2007; 56(12): 1735-1741.
11. Yun KE, Kim SM, Choi KM, Park HS. Association between adipocyte fatty acid-binding protein levels and childhood obesity in Korean children. Metabolism 2009; 58(6):798-802. doi: 10.1016/j.metabol.2009.01.017.
12. Khalyfa A, Bhushan B, Hegazi M, Kim J, Kheirandish-Gozal L, Bhattacharjee R, et al. Fatty-acid binding pro- tein 4 gene variants and childhood obesity: potential implications for insulin sensitivity and CRP levels. Lipids Health Dis 2010;15(9):18. doi: 10.1186/1476-511X-9-18.
13. Choi KM, Yannakoulia M, Park MS, Cho GJ, Kim JH, Lee SH, et al. Serum adipocyte fatty acid-binding protein, retinol-binding protein 4, and adiponectin concentrations in relation to the development of the metabolic syndrome in Korean boys: a 3-y prospective cohort study. Am J Clin Nutr 2011; 93(1):19-26. doi: 10.3945/ajcn.2010.29667.
14. Corripio R, Gónzalez-Clemente JM, Pérez-Sánchez J, Näf S, Gal- lart L, Nosàs R, et al. Weight loss in prepubertal obese children is associated with a decrease in adipocyte fatty-acid-binding protein without changes in lipocalin-2: a 2-year longitudinal study. Eur J Endocrinol 2010; 163(6): 887-893. doi: 10.1530/EJE-10-0408.
15. Pou KM, Massaro JM, Hoffmann U, Lieb K, Vasan RS, O’Donnell CJ, Fox CS. Patterns of Abdominal Fat Distribution. The Framingham Heart Study. Diabet Care 2009; 32(3): 481-485. doi: 10.2337/dc08-1359.
16. Desprès J-P, Lamarche B. Effects of diet and physical activity on adiposity and body fat distribution: implications for the prevention of cardiovascular disease. Nutr Res Rev 1993;6(1):137-159. doi: 10.1079/NRR19930010.
17. Bessesen DH. Update on Obesity. J Clin Endocrinol Metabol 2008; 93(6): 2027-2034. doi: 10.1210/jc.2008-0520.
18. Asayama K, Hayashibe H, Dobashi K, Uchida N, Nakane T, Kodera K, Shirahata A, Taniyama M. Decrease in serum adiponectin level due to obesity and visceral fat accumulation in children. Obes Res 2003; 11(9): 1072-1079.
19. Петеркова В.А., Косыгина А.В., Васюкова О.В. Адипонектин сыворотки крови при ожирении у детей и подростков. // Проблемы эндокринологии. - 2011. - Т.57. - №6 - С.9-14.
20. Després JP, Nadeau A, Tremblay A, Ferland M, Moorjani S, Lupien PJ, Thériault G, Pinault S, Bouchard C. Role of deep abdominal fat in the association between regional adipose tissue distribution and glu- cose tolerance in obese women. Diabetes 1989; 38(3): 304-309.
21. Kanai H, Matsuzawa Y, Kotani K, Keno Y, Kobatake T, Nagai Y, Fu- jioka S, Tokunaga K, Tarui S. Close correlation of intra-abdominal fat accumulation to hypertension in obese women. Hypertansion 1990; 16(5): 484-490.
22. Melka MG, Abrahamowicz M, Leonard GT, Perron M, Richer L, Veillette S, Gaudet D, Paus T, Pausova Z. Clustering of the Metabolic Syndrome Components in Adolescence: Role of Visceral Fat. PLoS One 2013; 8(12): e82368. doi: 10.1371/journal.pone.0082368.
23. Goodwin K, Syme C, Abrahamowicz M, Leonard GT, Richer L, Per- ron M, Veillette S, Gaudet D, Paus T, Pausova Z. Routine clinical measures of adiposity as predictors of visceral fat in adolescents: a population-based magnetic resonance imaging study. PLoS One 2013; 8(11): e79896. doi: 10.1371/journal.pone.0079896.
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For citations:
Okorokov P.L., Vasyukova O.V., Vorontsov A.V., Ilyin A.V., Vladimirova V.P., Averkieva E.V. The levels of adipocyte protein, a transporter of fatty acids, and adiponectin in the adolescents presenting with obesity and their relationship with the distribution of the adipose tissue. Problems of Endocrinology. 2014;60(2):13-19. (In Russ.) https://doi.org/10.14341/probl201460213-19
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