The state of the blood antioxidant system in the patients presenting with acromegaly
https://doi.org/10.14341/probl20156128-11
Abstract
The state of the blood antioxidant system in the patients presenting with acromegaly. The objective of the present study was to evaluate the total antioxidant activity (TAA) of blood plasma, the levels of non-protein thiols and 2-thyobarbituric acid-active products (TBA-AP), superoxide dismutase (SOD) and catalase (CAT) activities as well as ceruloplasmin (CP) level in the patients presenting with acromegaly. It was shown that plasma TAA and SOD activity in this patients was on the average 20 and 30% lower respectively than in the control subjects. At the same time, the TBA-AP and CP levels increased by 50 and 40% respectively. These data suggest the development of oxidative stress in the acromegalic patients.
About the Authors
M V Faassen
Endocrinology Research Centre, Moscow
M S Pankratova
Endocrinology Research Centre, Moscow
N N Molitvoslovova
Endocrinology Research Centre, Moscow
A A Baizhumanov
M.V. Lomonosov Moscow State University, Moscow
S S Kovalenko
M.V. Lomonosov Moscow State University, Moscow
A I Yusipovich
M.V. Lomonosov Moscow State University, Moscow
G V Maksimov
M.V. Lomonosov Moscow State University, Moscow
V A Peterkova
Endocrinology Research Centre, Moscow
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Review
For citations:
Faassen M.V., Pankratova M.S., Molitvoslovova N.N., Baizhumanov A.A., Kovalenko S.S., Yusipovich A.I., Maksimov G.V., Peterkova V.A. The state of the blood antioxidant system in the patients presenting with acromegaly. Problems of Endocrinology. 2015;61(2):8-11. (In Russ.) https://doi.org/10.14341/probl20156128-11
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