Papillary thyroid cancer, Hashimoto’s thyroiditis, adenomatoid hyperplasia. Do they have any connection?

Introduction. While thyroid nodules are extremely pervasive, the chances that a nodule is malignant are small. The annual incidence of thyroid carcinoma is 0,5-10 per 100000. A hefty 75-80% of all thyroid carcinoma cases are papillary thyroid carcinoma, which is referred to as differentiated thyroid carcinoma.

Relevancy. Papillary thyroid carcinoma is the most common thyroid carcinoma. Peak onset ages are from 40 to 60 years old. Furthermore the increasing incidence has been observed among younger people. With the discovery of a thyroid nodule, a complete history and physical examination focusing on the thyroid gland should be performed.

Aim: to determine papillary carcinoma’s background pathology, proceed the ubiquitous approach of thyroid nodule’s diagnosis, dynamic control and treatment.

Material and Methods. This study covered the period of 2010-2014. 183 patients attending Erebuni medical center’s General and Endocrine Surgery Department were included in this analysis. Postoperative pathohistological examination has authenticated the diagnosis: papillary thyroid carcinoma. The study has not included the patients who underwent only preoperative cytological examination without postoperative pathohistological diagnosis and the patients who underwent surgical treatment for the relapse.

Results. In a massive 53,6%(98) of 183 observed patients' papillary thyroid carcinoma has occurred de novo. However 46,4%(85) has had background pathology such as Hashimoto's thyroiditis(18,6%(34)) and Adenomatoid hyperplasia (27,8%(51)). A major 59,6%(109) has been above 40 years old, the other 40,4% has been under 40.

Conclusion. To sum up there might be a possible connection between papillary carcinoma, Hashimoto's thyroiditis and Adenomatoid hyperplasia. We suggest ultrasound follow-up and double cytological examination(if the previous one is mistrustful) among patients who have Hashimoto's thyroiditis(ultrasound examination confirmation, high level of antibodies) and Adenomatoid hyperplasia( cytological examination confirmation).