Insulin autoimmune syndrome: a rare cause of hypoglycemia. The case report of the syndrome in pediatric practice
https://doi.org/10.14341/probl2017633189-194
Abstract
Insulin autoimmune syndrome (IAS) is characterized by spontaneous hypoglycemia accompanied by an increased insulin level and presence of insulin autoantibodies while no exogenous insulin was used. This disorder is the third leading cause of hypoglycemia in Southeastern Asia. The disorder develops in individuals with a genetic predisposition, mostly after they had administered drugs containing a sulfhydryl moiety, such as methimazole, penicillin g, etc. The syndrome is typical of adults and extremely rare among children. We report the case of developing IAS in a 3.5-year-old Caucasian girl, possibly induced by pyritinol therapy.
About the Authors
Elena S. KuznetsovaEndocrinology Research Centre
Russian Federation
MD
Oxana V. Pilipenko
Children’s City Clinical Hospital no.1
Russian Federation
MD
Maria А. Melikyan
Endocrinology Research Centre
Russian Federation
MD, PhD
References
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Supplementary files
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1. Рис. 1. Результаты орального глюкозотолерантного теста. | |
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2. Рис. 2. Динамика лабораторных показателей у пациентки в ходе наблюдения. | |
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3. Рис. 3. Строение молекулы пиритинола. | |
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Review
For citations:
Kuznetsova E.S., Pilipenko O.V., Melikyan M.А. Insulin autoimmune syndrome: a rare cause of hypoglycemia. The case report of the syndrome in pediatric practice. Problems of Endocrinology. 2017;63(3):189-194. https://doi.org/10.14341/probl2017633189-194
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