The content of bioactive and immunoreactive luteinizing hormone in the blood during injections of gonadotropin releasing factor to patients with pituitary adenoma
Abstract
The secretion of bioactive (LHb) and immunoreactive (LHj) in response to gonadotropic hormone releasing factor (GHRF) was assessed in 8 women with pituitary macroadenoma (gonadotropinoma) and 6 patients with pituitary microadenoma combined with the polycystic ovaries syndrome. GHRF more intensively stimulated the secretion of LHb in patients with macroadenoma than that of LHj. If the level of estrogens in the blood increases, the secretion of LHb decreases in comparison with the production of LHi. In patients with pituitary microadenoma combined with the polycystic ovaries syndrome GHRF stimulated the secretion of LHj more intensively than that of LHb.
About the Authors
N. P. GoncharovEndocrinology Research Center RAMS
Russian Federation
A. D. Dobracheva
Endocrinology Research Center RAMS
Russian Federation
V. V. Vaks
Endocrinology Research Center RAMS
Russian Federation
I. S. Yarovaya
Endocrinology Research Center RAMS
Russian Federation
N. B. Akopova
Endocrinology Research Center RAMS
Russian Federation
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Review
For citations:
Goncharov N.P., Dobracheva A.D., Vaks V.V., Yarovaya I.S., Akopova N.B. The content of bioactive and immunoreactive luteinizing hormone in the blood during injections of gonadotropin releasing factor to patients with pituitary adenoma. Problems of Endocrinology. 1997;43(1):19-22. (In Russ.)
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