The role of intercellular interactions in the liver in the implementation of the cooperative effect of glucocorticoids and blood lipoproteins
https://doi.org/10.14341/probl199945631-33
Abstract
Ultrastructural studies confirmed the functional relationship between the nonparenchymatous cells of the liver and hepatocytes during blood glucocorticoid and lipoprotein metabolism. Lipopolysaccharide stimulation of macrophages induced a parallel decrease in the blood glucocorticoid concentration and share of HDLP3 and LDLP in the lipoprotein spectrum. In vitro experiments demonstrated that it involved a sharp increase in the capture and transcytosis of labeled lipoproteins (particularly HDLP3) through sinusoidal cells. Alteration of the hepatocyte nuclei is a morphological manifestation of the cooperative effect of glucocorticoids and HDLP3 and less so of the joint effect of glucocorticoids and LDLP. Stimulation of macrophages leads to an increase in the relative volume of the nucleoli in the nuclei and in the content of the granular substance in them, and in the compactness of porous complexes. These rearrangements are an obligatory condition for gene expression and intensification of protein production in hepatocytes.
About the Authors
L. E. PaninInstitute of Biochemistry, Siberian Branch of the Russian Academy of Medical Sciences
Russian Federation
I. M. Korostyshevskaya
Institute of Biochemistry, Siberian Branch of the Russian Academy of Medical Sciences
Russian Federation
V. F. Maksimov
Institute of Biochemistry, Siberian Branch of the Russian Academy of Medical Sciences
Russian Federation
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Review
For citations:
Panin L.E., Korostyshevskaya I.M., Maksimov V.F. The role of intercellular interactions in the liver in the implementation of the cooperative effect of glucocorticoids and blood lipoproteins. Problems of Endocrinology. 1999;45(6):31-33. (In Russ.) https://doi.org/10.14341/probl199945631-33
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