The oxidative effects of melatonin, the content of citrate and the activity of aconitate hydratase in the rat liver in toxic hepatitis
https://doi.org/10.14341/probl200551641-43
Abstract
When melatonin was injected into the liver of rats with toxic hepatitis, there was a reduction in the rate of free radical processes and in the mobilization of the antioxidative system, as estimated by the parameters of biochemiluminescence and the level of α-tocopherol, which is likely to be accounted for by the antioxidative effect of this hormone. The administration of melatonin to intact animals causes a reduction in the activity of aconitate hydratase and an increase in the level of citrate, which reflects the enhancement of the antioxidative potential as it promotes the decreased hydroxyl radical formation in the Fenton reaction. Metatonin-induced elevations in citrate levels and changes in the activity of aconitate hydratase were observed in the liver of animals with toxic hepatitis as compared with those not receiving the hormone, which seems to be associated with the less mobilization of the antioxidative system in the presence of melatonin that is able to produce an antioxidative effect.
About the Authors
A. N. PashkovVoronezh State Medical University
Russian Federation
S. S. Popov
Voronezh State Medical University
Russian Federation
A V Semenikhina
Voronezh State University
Russian Federation
L. V. Matasova
Voronezh State University
Russian Federation
T. N. Popova
Voronezh State University
Russian Federation
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Review
For citations:
Pashkov A.N., Popov S.S., Semenikhina A.V., Matasova L.V., Popova T.N. The oxidative effects of melatonin, the content of citrate and the activity of aconitate hydratase in the rat liver in toxic hepatitis. Problems of Endocrinology. 2005;51(6):41-43. (In Russ.) https://doi.org/10.14341/probl200551641-43
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