Impact of iodine deficiency on the thyroid and neuromental development in children with neonatal transient hypothyroidism
https://doi.org/10.14341/probl200652515-17
Abstract
Ninety-five preschool age children living in an iodine deficiency area were examined. Neonatal screening forcongenital hypothyroidism showed that 79 and 16 children had a thyroid-stimulating hormone (TSH) level of 20-50 and 51-100 uIU/ml, respectively, which became normal in the first 6 months of life. A control group comprised 35 children of the same age who had a TSH level of as high as 20 uIU/ml. A study of thyroid function revealed subclinical hypothyroidism in 16.8% of cases and an isolated increase in free triiodothyronine with the normal levels of TSH and free T«. Volumetry Indicated detected thyroid hypoplasia in 36.8% of the children. In the study group, the neuropsychological development Index was 90-110scores in 38(40.0%) children, 80-89 scores in 24(25.3%), and less than 80 scores In 33 (34.7%). The found changes in the pituitary-thyroid system in the study group determine a risk for thyroid disease and cognitive defects, which requires a follow-up of such children and drug correction of thyroid function.
About the Author
U F Nasirova
Ташкентский педиатрический медицинский институт Минздрава Республики Узбекистан
References
1. Ашурова Л. 3., Убайдуллаева Н. Б., Шарыпова Ф. К., Зуфа-рова Д. С. // Врач обшей практики. - 2002. - № 3. - С. 40-42.
2. Герасимов Г. А, Фадеев В. В, Свириденко И. Ю. и др. // Простое решение сложной проблемы. - М.. 2002.
3. Долгов В. В., Шабанова И. П., Гигель Е. П., Шилин Д. Е. // Лабораторная диагностика заболеваний щитовидной железы. - М., 2002. - С. 98.
4. Кисилева Е. В., Самсонова Л. И., Ибрагимова Г. В. и др. // Пробл. эндокринол. - 2003. - № 5. - С. 30-32.
5. Коваленко Г. В., Петрова И. И. // Педиатрия. - 2001. - № 3. - С. 25-28.
6. Профилактика и лечение йододефицитных заболеваний в группах повышенного риска. Пособие для врачей / Дедов И. И., Мельниченко Г. А., Трошина Е. А. и др. - 2004.
7. Пыков М. И., Ватолигина К. В. // Детская ультразвуковая диагностика. - М., 2001. - С. 556-591.
8. Щеплягина Л. А. // Рос. педиатр, журн. - 1999. - № 4. - С. И.
9. Clinoer D., Delange F. // Thyroid. - 2000. - Vol. 10. - P. 871-887.
10. Normal Reference Laboratory Values // N. Engl. J. Med. - 1998. - Vol. 339. - P. 1063-1072.
Review
For citations:
Nasirova U.F. Impact of iodine deficiency on the thyroid and neuromental development in children with neonatal transient hypothyroidism. Problems of Endocrinology. 2006;52(5):15-17. (In Russ.) https://doi.org/10.14341/probl200652515-17
Views:
345
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND 4.0).
Email this article 
.jpg){kind=logo}
