Correlation Level of HbA1с and postprandial glycemia in type 2 diabetes in the oral glucose tolerance test

A number of today's analytical methods for postprandial glycemia in the oral glucose tolerance test (OGTT) still remain to be substantiated. The standard OGTT using 75 g of glucose was performed in 42 type 2 diabetes mellitus (DM-2) patients who received diet therapy. The concentration of Hb A_1c has been found to correlate with absolute levels of glycemia during 1- and 2-hour OGTT. However, exclusion of fasting glycemia from the level of glycemia at 1 and 2 hours of OGTT leads to cession of the correlation of HbA_1c with these values of the test. Only 7 out of the 8 today's parameters for calculating the areas under the glycemic curve in OGTT correlate with the level of HbA_1c. Moreover, 5 out of these 7 parameters are equivalent (r - 1; p < 0.05). The recently proposed two new parameters for calculating the areas under the glycemic curve in OGTT, one of which is constant 6.1, have proved to be equivalent (r= 1; p < 0 05) and to be actually reduced to one. The correlation with Hb A_h holds if any other constants from 5 to 11 mmоl/l are inserted instead of the constant 6.1 for calculating the area, the highest coefficient correlation with Hb A_1c is achieved at the constant equal to 6.1. The correlation usually detectable at DM-2 between the concentration of Hb A,_c and the absolute level of postprandial glycemia (glycemic spike in particular) Is mainly determined by its implicit inclusion of fasting glycemia. A set of 4 nonequivalent OGTT parameters should be used when the relationship of diabetes mellitus complications to the OGTT parameters that correlate with HbA,_cis studied. The constants 5.6 and 6.1 reflect different aspects of the development of complications in diabetes mellitus when they are included in the calculation of an area in OGTT.

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