Sex hormone receptors in pituitary prolactinomas
https://doi.org/10.14341/probl200753142-46
Abstract
An attempt was made to interpret the mechanism responsible for the occurrence of pituitary tumors - prolactinoma in persons of different sex. The presence or absence of androgenic receptors in the tumors was studied. Analysis of the concentration of nuclear receptors, estrogen ones in particular, showed their higher concentration in prolactin-positive pituitary adenomas than in inactive pituitary adenomas. Androgen receptors were detected in the gonadotropic and lactotropic cells of the Intact pituitary. Analysis of the concentration of nuclear testosterone receptors in different morphological types of pituitary adenomas revealed no differences in the luteinizing hormone/follicle-stimulating hormone-positive and prolactin-positive tumors
About the Authors
V. N. BablchevEndocrinology Research Centre
Russian Federation
E. I. Marova
Endocrinology Research Centre
Russian Federation
T. A. Kuznetsova
Endocrinology Research Centre
Russian Federation
E. I. Adamskaya
Endocrinology Research Centre
Russian Federation
B. A. Kadashev
N.N. Burdenko Institute of Neurosurgery of the Rusian academy of medical sciences
Russian Federation
L. I. Astafyeva
N.N. Burdenko Institute of Neurosurgery of the Rusian academy of medical sciences
Russian Federation
O. N. Yatsishina
N.N. Burdenko Institute of Neurosurgery of the Rusian academy of medical sciences
Russian Federation
A. N. Shkarubo
N.N. Burdenko Institute of Neurosurgery of the Rusian academy of medical sciences
Russian Federation
References
1. Бабичев В. Н., Марова Е. И., Кузнецова Т. А. и др. // Пробл. эндокринол. - 2000. - Т. 46, № 5. - С. 33-35.
2. Бабичев В. Н., Марова Е. И., Кузнецова Т. А. и др. // Бюл. экспер. биол. - 2001. - Т. 131, № 4. - С. 369-372.
3. Бабичев В. Н. // Биомед. химия. - 2005. - Т. 51, вып. 6. -С. 603-616.
4. Кедрова В. М., Орлова Л. В. // Современные методы в биохимии. - М., 1968. - С. 59-71.
5. Anderson J. N., Clark J. H., Peck E. J. // Biochem. J. - 1972. -Vol. 126, N 4. - P. 561-567.
6. Asa S. L., Cheng Z., Ramyar L. et al. // J. Clin. Endocrinol. Metab. - 1992. - Vol. 74. - P. 1128-1134.
7. Arafah B. M., Wilhite B. L. et al. // J. Clin. Endocrinol. Metab. - 1983. - Vol. 57. - P. 986-992.
8. Asa S. L., Ezzat S. The Cytogenesis and Pathogenesis of Pituitary Adenomas. - New York, 1998.
9. Burton K.A. // Biochem. J. - 1956. - Vol. 62. - P. 315-323.
10. Caronti В., Palladinl G., Calderaro С. et al. // Tumour Biol. - 1995. - Vol. 16. - P. 353-364.
11. Friend K. E, Chiou Y. K, Lopes M. B. et al. // J. Clin. Endocrinol. Metab. - 1994. - Vol. 78. - P. 1497-1504.
12. Gittoes N.. McCabe С/J., Verhaeg J. et al. // J. Clin. Endocrinol. Metab. - 1997. - Vol. 82. - P. 1960-1967.
13. Grossman A., Besser G. M. // Br. Med. J. - 1985. - Vol. 290. -P. 182-184.
14. Holmgren U., Bergstraund G., Hagenfeldt K., Werner S. // Acta Endocrinol. (Copenh.). - 1986. - Vol. 111. - P. 452-459.
15. Horvath E, Kovach K. // Am. J. Pathol. - 1984. - Vol. 117. -P. 440.
16. Hubert J. F., Thibault I., Turcotte R., Labric F. // Neuroendo-crinology. - 1988. - Vol. 48. - P. 360-366.
17. Jgnar-Trowbridge D. M., Pimentel M., Parker M. G. et al. // Endocrinology. - 1996. - Vol. 137. - P. 1735-1744.
18. Jaffrain-Rea M. L., Petrangeli E, Ortolanl F. et al. // J. Endocrinol. - 1996. - Vol. 151. - P. 175-184.
19. Kovacs K., Stefaneonu L., Horvath E. et al. // Virchows Arch. (Pathol. Anat.). - 1990. - Vol. 418. - P. 439-446.
20. Kovacs K., Stefaneanu L., Ezzat S., Smith H. S. // Arch. Pathol. Lab. Med. - 1994. - Vol. 118. - P. 562-565.
21. Lamberts S. W. J., Verleun Т., Oosterom R. // Neuroendocrinology. - 1982. - Vol. 34. - P. 339-342.
22. Lamberts S. W. J., van Koetsvell P., Verleun T. // Cancer Res. -1987. - Vol. 47. - P. 3666-3671.
23. Lloyd R. V. // J. Pathol. - 1983. - Vol. 113. - P. 198-206.
24. Nakao H., Koda M., Arao M. et al. // Acta Endocrinol. (Copenh.). - 1989. - Vol. 120. - P. 233-238.
25. Petllon F., Vila-Porcile E., Olivier L., Racadot J. // Ann. Endocrinol. - 1970. - Vol. 31. - P. 259-270.
26. Pelletter G. // Histol. Histopathol. - 2000. - Vol. 15. -P. 1261-1270.
27. Saeger W., Schreiber S., Ludecke D. K. // Pathol. Res. Pract. - 2000. - Vol. 196. - P. 771-773.
28. Shupnik M. A., Pitt L. K., Soh A. G. et al. // J. Clin. Endocrinol. Metab. - 1998. - Vol. 83. - P. 3965-3972.
29. Sprangen S. A., West N. В., Brenner R. M., Nethea С.L. // Endocrinology. - 1990. - Vol. 126. - P. 1133-1142.
30. Stefaneanu L., Kovacs K., Horvath E. et al. // J. Clin. Endocrinol. Metab. - 1994. - Vol. 78. - P. 83-88.
31. Stefaneanu L.. // Endocr. Pathol. - 1997. - Vol. 8. - P. 91-108.
32. Zafar M., Ezzat S., Ramyar L. et al. // J. Clin. Endocrinol. Metab. - 1995. - Vol. 80. - P. 3621-3627.
Review
For citations:
Bablchev V.N., Marova E.I., Kuznetsova T.A., Adamskaya E.I., Kadashev B.A., Astafyeva L.I., Yatsishina O.N., Shkarubo A.N. Sex hormone receptors in pituitary prolactinomas. Problems of Endocrinology. 2007;53(1):42-46. (In Russ.) https://doi.org/10.14341/probl200753142-46
Views:
2277
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND 4.0).
Email this article 
.jpg){kind=logo}
