Efficiency of treatment for diffuse toxic goiter in relation to the estimated therapeutic activity of radioactive iodine
https://doi.org/10.14341/probl200753245-48
Abstract
Forty-eight patients with diffuse toxic goiter (Graves's disease) were treated with radioactive iodine in a dose of 5.3-30.0 mCi. A special formula considering the volume of the thyroid and post-24-hour capture of the diagnostic activity of radioactive iodine was used to calculate the optimum therapeutic activity. As a result, specific therapeutic activity (STA) correlated with specific activity and with the volume of thyroid. The high rate (33.3%) of recurrent thyrotoxicosis was observed when the calculated STA was less than 0 3 mCi/ml and reduced to 11.1% if a greater activity was applied. The use of the standard activity of radioactive iodine (10mCi) with a thyroid volume of up to 40 ml, as compared to that calculated by the formula results in the similar rate of ineffective radioiodine therapy for thyrotoxicosis at a lower incidence of euthyrosis.
About the Authors
A. V. DrevalMoscows regional research clinical institute n.a. M.F. Vladimirskiy
Russian Federation
A. F. Tsub
Medical Research Radiological Center of the Russian Academy of Medical Sciences
Russian Federation
O. A. Nechayeva
Moscows regional research clinical institute n.a. M.F. Vladimirskiy
Russian Federation
I. V. Komerdus
Moscows regional research clinical institute n.a. M.F. Vladimirskiy
Russian Federation
B. Ya. Drozdovsky
Medical Research Radiological Center of the Russian Academy of Medical Sciences
Russian Federation
P. I. Garbuzov
Medical Research Radiological Center of the Russian Academy of Medical Sciences
Russian Federation
T. N. Guseva
Medical Research Radiological Center of the Russian Academy of Medical Sciences
Russian Federation
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Review
For citations:
Dreval A.V., Tsub A.F., Nechayeva O.A., Komerdus I.V., Drozdovsky B.Ya., Garbuzov P.I., Guseva T.N. Efficiency of treatment for diffuse toxic goiter in relation to the estimated therapeutic activity of radioactive iodine. Problems of Endocrinology. 2007;53(2):45-48. (In Russ.) https://doi.org/10.14341/probl200753245-48
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