The reference values of 17-hydroxyprogesterone and dehydroepiandrosterone in the gestational period

Abstract

Hyperandrogenism has a considerable negative impact on the course of pregnancy. The measurement of the levels of 17-hydroxy-progesterone and dehydroepiandrosterone sulfate as markers of adrenal hyperandrogenism, without taking into account the gestational metabolism of the hormones, promotes the hyperdiagnosis of nonclassical forms of congenital adrenal cortex dysfunction and involves inadequate treatment policy. The isolated elevation of dehydroepiandrosterone sulfate is not attended by an increase in the incidence of androgen-dependent complications of pregnancy