Risk factors of thyrotoxic cardiomyopathy
https://doi.org/10.14341/probl200753422-25
Abstract
A retrospective study covered 272 patients (mean age 54 years) admitted for different forms of toxic goiter concurrent with cardiac arrhythmias and/or sings with heart failure (HF), which was undertaken to explore risk factors of thyrotoxic cardiomyopathy (TTCM). Cardiac arrhythmias following the pattern of sinus tachycardia and/or supraventricular extrasystole without signs of HF were observed ПРОБЛЕМЫ ЭНДОКРИНОЛОГИИ. 2007. Т. 53, № 4. in S3 (19.5%) out of the 272 patients (a mild TTCM group - TTCM-1) whereas cardiac arrhythmias as atrial fibrillations and/or flutters and/or the devebpment of HF In the presence of thyrotoxicosis (TT) were detected in 219 (80.5%) of the 272 patients (a severe TTCM group - TTCM-2). Indices, such as admission age, an interval between TT detection and the initiation of treatment, a history of endocrine ophthalmopathy and cardiovascular pathology, were examined in the regression analysis considering the severe course of TTMC as a poor predictor. Comparison of the groups revealed statistically significant differences in such Indices, as the interval between TT identification to therapy (OR = 1.8; 95% CI = 1.06-3.13; p = 0.02) and the patients' age at the moment of admission (OR = 1.1, 95% CI = 1.02-1.15; p= 0.01).
About the Authors
V. Yu. ShulginaEndocrinology Research Centre
Russian Federation
V. V. Fadeyev
I.M.Sechenov Moscow Medical Academy
Russian Federation
G. A. Metnichenko
Endocrinology Research Centre
Russian Federation
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Review
For citations:
Shulgina V.Yu., Fadeyev V.V., Metnichenko G.A. Risk factors of thyrotoxic cardiomyopathy. Problems of Endocrinology. 2007;53(4):22-25. (In Russ.) https://doi.org/10.14341/probl200753422-25
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