Renal excretion of insulin-like growth factor 1 and vascular endothelial growth factor in patients with type 1 diabetes with nephropathy
https://doi.org/10.14341/probl20075363-7
Abstract
Thе aim of the investigation was to study the urinary excretion of insulin-like growth factor 1 (ICF-1) and vascular endothelial growth factor (VEGF) at different stages of nephropathy in 57 patients with type 1 diabetes, including 22 patients with normal albuminuria, 23 with microalbuminuria, and 12 with proteinuria. The excretion of IGF-1 and VEGF was increased in the microalbu-minuric and proteinuric patients as compared with the controls (1GF-1: p = 0.004 and p = 0.00005; VEGF: p = 0.06 and p = 0.02). That of growth factors inversely correlated with glomerular filtration rates and hemoglobin levels (IGF-1: r = -0.43 and r = -0.41; VEGF: r = -0.14 and r - -0.27). In the normo- and microalbuminuric patients, IGF-1 excretion was associated with the thickness of glomerular and tubular basement membranes (r = 0.59 and r = 0.53, respectively) and with the number of podocytic foot processes (r = -0.69). VEGF correlated with the volume of the mesangium (r = 0.69) and the thickness of the glomerular basement membrane (r = 0.53). IGF-1 rather than VEGF positively correlated with HbA1c (r = 0.47 and r = 0.02). It has been concluded that in patients with type I diabetes, the increased urinary excretion of IGF-1 and VEGF is associated with the development of nephropathy and may be used for the early diagnosis of this complication.
About the Authors
I. A. BondarNovosibirsk State Medical University
Russian Federation
V. V. Klimentov
Novosibirsk State Medical University
Russian Federation
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Review
For citations:
Bondar I.A., Klimentov V.V. Renal excretion of insulin-like growth factor 1 and vascular endothelial growth factor in patients with type 1 diabetes with nephropathy. Problems of Endocrinology. 2007;53(6):3-7. (In Russ.) https://doi.org/10.14341/probl20075363-7
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